Impact of concurrent chemotherapy on definitive radiotherapy for women with FIGO IIIb cervical cancer
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Authors
Kuroda, Yuuki
Murakami, Naoya
Morota, Madoka
Sekii, Shuhei
Takahashi, Kana
Inaba, Koji
Mayahara, Hiroshi
Ito, Yoshinori
Yoshimura, Ryo-ichi
Sumi, Minako
Issue Date
2012-06-15
Type
Article
Language
en_US
Keywords
Cervical Cancer , IIIb , Chemotherapy , Radiotherapy , HDR
Alternative Title
Abstract
The purpose of this retrospective study is to investigate the impact of concurrent chemotherapy on definitive radiotherapy for the International Federation of Gynecology and Obstetrics (FIGO) IIIb cervical cancer. Between 2000 and 2009, 131 women with FIGO IIIb cervical cancer were treated by definitive radiotherapy (i.e. whole pelvic external beam radiotherapy for 40–60 Gy in 20–30 fractions with or without center shielding and concomitant high-dose rate intracavitary brachytherapy with 192-iridium remote after loading system for 6 Gy to point A of the Manchester method). The concurrent chemotherapy regimen was cisplatin (40 mg/m2/week). After a median follow-up period of 44.0 months (range 4.2–114.9 months) and 62.1 months for live patients, the five-year overall survival (OS), loco-regional control (LRC) and distant metastasis-free survival (DMFS) rates were 52.4, 80.1 and 59.9%, respectively. Univariate and multivariate analyses revealed that lack of concurrent chemotherapy was the most significant factor leading to poor prognosis for OS (HR = 2.53; 95% CI 1.44–4.47; P = 0.001) and DMFS (HR = 2.53; 95% CI 1.39–4.61; P = 0.002), but not for LRC (HR = 1.57; 95% CI 0.64–3.88; P = 0.322). The cumulative incidence rates of late rectal complications after definitive radiotherapy were not significantly different with or without concurrent chemotherapy (any grade at five years 23.9 vs 21.7%; P = 0.669). In conclusion, concurrent chemotherapy is valuable in definitive radiotherapy for Japanese women with FIGO IIIb cervical cancer.
Description
Citation
Kuroda, Y., Murakami, N., Morota, M., Sekii, S., Takahashi, K., Inaba, K., Mayahara, H., Ito, Y., Yoshimura, R., Sumi, M., Kagami, Y., Katsumata, N., Kasamatsu, T., & Itami, J. (2012). Impact of concurrent chemotherapy on definitive radiotherapy for women with FIGO IIIb cervical cancer. Journal of radiation research, 53(4), 588–593. https://doi.org/10.1093/jrr/rrs010
Publisher
Journal of Radiation Research