Determination of an optimal standardized uptake value of fluorodeoxyglucose for positron emission tomography imaging to assess pathological volumes of cervical cancer: a prospective study
Loading...
Authors
Zhang, Ying
Hu, Jing
Lu, Hong-Jun
Li, Jian-Ping
Wang, Ning
Li, Wei-Wei
Zhou, Yong-Chun
Liu, Jun-Yue
Wang, Sheng-Jun
Wang, Jing
Issue Date
2013-11-12
Type
Article
Language
en_US
Keywords
Determination , Fluorodeoxyglucose , Positron Emission Tomography Imaging , Pathological Volumes , Cervical Cancer
Alternative Title
Abstract
Purpose:
To determine the optimal standardized uptake value (SUV) of 18F-fluorodeoxyglucose (18F-FDG) for positron emission tomography (PET) imaging, at which the PET-defined gross tumor volume (GTVPET) best matches with the pathological volume (GTVPATH) in the cervical cancer.
Materials and Methods:
Ten patients with the cervical cancer who underwent surgery were enrolled in this study. The excised specimens were processed for whole-mount serial sections and H-E staining. The tumor borders were outlined in sections under a microscope, histopathological images were scanned and the GTVPATH calculated. The GTVPET was delineated automatically by using various percentages relative to the maximal SUV and absolute SUV. The optimal threshold SUV was further obtained as the value at which the GTVPET best matched with the GTVPATH.
Results:
An average of 85±10% shrinkage of tissue was observed after the formalin fixation. The GTVPATH was 13.38±2.80 cm3 on average. The optimal threshold on percentile SUV and absolute SUV were 40.50%±3.16% and 7.45±1.10, respectively. The correlation analysis showed that the optimal percentile SUV threshold was inversely correlated with GTVPATH (p<0.05) and tumor diameter (p<0.05). The absolute SUV was also positively correlated with SUVmax (p<0.05).
Conclusion:
The pathological volume could provide the more accurate tumor volume. The optimal SUV of FDG for PET imaging by use of GTVPATH as standard for cervical cancer target volume delineation was thus determined in this study, and more cases are being evaluated to substantiate this conclusion.
Description
Citation
Zhang, Y., Hu, J., Lu, H. J., Li, J. P., Wang, N., Li, W. W., Zhou, Y. C., Liu, J. Y., Wang, S. J., Wang, J., Li, X., Ma, W. L., Wei, L. C., & Shi, M. (2013). Determination of an optimal standardized uptake value of fluorodeoxyglucose for positron emission tomography imaging to assess pathological volumes of cervical cancer: a prospective study. PloS one, 8(11), e75159. https://doi.org/10.1371/journal.pone.0075159
Publisher
PloS One