HPV16 variant lineage, clinical stage, and survival in women with invasive cervical cancer
Loading...
Authors
Zuna, Rosemary E.
Tuller, Erin
Wentzensen, Nicolas
Mathews, Cara
Allen, Richard A.
Shanesmith, Rebecca
Dunn, S Terence
Gold, Michael A.
Wang, Sophia S.
Walker, Joan
Issue Date
2011-10-28
Type
Article
Language
en_US
Keywords
Cervical Neoplasms , Human Papillomavirus 16 , HPV16 Variants
Alternative Title
Abstract
Background:
HPV16 variants are associated with different risks for development of CIN3 and invasive cancer, although all are carcinogenic. The relationship of HPV 16 variants to cancer survival has not been studied.
Methods:
155 HPV16-positive cervical cancers were categorized according to European and non-European variant patterns by DNA sequencing of the E6 open reading frame. Clinico-pathologic parameters and clinical outcome were collected by chart review and death registry data.
Results:
Of the 155 women (mean age 44.7 years; median follow-up 26.7 months), 85.2% harbored European variants while 14.8% had non-European sequences. HPV16 variants differed by histologic cell type (p = 0.03) and stage (1 vs. 2+; p = 0.03). Overall, 107 women (68.0%) were alive with no evidence of cancer, 42 (27.1%) died from cervical cancer, 2 (1.3%) were alive with cervical cancer, and 4 (2.6%) died of other causes. Death due to cervical cancer was associated with European variant status (p < 0.01). While 31% of women harboring tumors with European variants died from cervical cancer during follow-up, only 1 of 23 (4.4%) non-European cases died of cancer. The better survival for non-European cases was partly mediated by lower stage at diagnosis.
Conclusions:
Overall, invasive cervical cancers with non-European variants showed a less aggressive behavior than those with European variants. These findings should be replicated in a population with more non-European cases.
Description
Citation
Zuna, R. E., Tuller, E., Wentzensen, N., Mathews, C., Allen, R. A., Shanesmith, R., Dunn, S. T., Gold, M. A., Wang, S. S., Walker, J., & Schiffman, M. (2011). HPV16 variant lineage, clinical stage, and survival in women with invasive cervical cancer. Infectious agents and cancer, 6, 19. https://doi.org/10.1186/1750-9378-6-19
Publisher
Infectious Agents and Cancer