Update on the use of nanocarriers and drug delivery systems and future directions in cervical cancer
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Authors
Himiniuc, Loredana Maria
Toma, Bogdan Florin
Popovici, Razvan
Grigore, Ana Maria
Hamod, Alexandru
Volovat, Constantin
Volovat, Simona
Nica, Irina
Vasincu, Decebal
Agop, Maricel
Issue Date
2022-05-04
Type
Article
Language
en_US
Keywords
Use of Nanocarriers , Drug Delivery Systems , Cervical Cancer
Alternative Title
Abstract
Cervical cancer represents a major health problem among females due to its increased mortality rate. The conventional therapies are very aggressive and unsatisfactory when it comes to survival rate, especially in terminal stages, which requires the development of new treatment alternatives. With the use of nanotechnology, various chemotherapeutic drugs can be transported via nanocarriers directly to cervical cancerous cells, thus skipping the hepatic first-pass effect and decreasing the rate of chemotherapy side effects. This review comprises various drug delivery systems that were applied in cervical cancer, such as lipid-based nanocarriers, polymeric and dendrimeric nanoparticles, carbon-based nanoparticles, metallic nanoparticles, inorganic nanoparticles, micellar nanocarriers, and protein and polysaccharide nanoparticles. Nanoparticles have a great therapeutic potential by increasing the pharmacological activity, drug solubility, and bioavailability. Through their mechanisms, they highly increase the toxicity in the targeted cervical tumor cells or tissues by linking to specific ligands. In addition, a nondifferentiable model is proposed through holographic implementation in the dynamics of drug delivery dynamics. As any hologram functions as a deep learning process, the artificial intelligence can be proposed as a new analyzing method in cervical cancer.
Description
Citation
Himiniuc, L. M., Toma, B. F., Popovici, R., Grigore, A. M., Hamod, A., Volovat, C., Volovat, S., Nica, I., Vasincu, D., Agop, M., Tirnovanu, M., Ochiuz, L., Negura, A., & Grigore, M. (2022). Update on the Use of Nanocarriers and Drug Delivery Systems and Future Directions in Cervical Cancer. Journal of immunology research, 2022, 1636908. https://doi.org/10.1155/2022/1636908
Publisher
Journal of Immunology Research