Effect of hyaluronate acid injection on dose-volume parameters in brachytherapy for cervical cancer

Kobayashi, Rei; Murakami, Naoya; Chiba, Takahito; Okuma, Kae; Inaba, Koji; Takahashi, Kana; Kaneda, Tomoya; Kashihara, Tairo; Takahashi, Ayaka; Shimizu, Yuri; Nakayama, Yuko; Kato, Tomoyasu; Ito, Yoshinori; Igaki, Hiroshi

Effect of hyaluronate acid injection on dose-volume parameters in brachytherapy for cervical cancer

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Authors

Kobayashi, Rei

Murakami, Naoya

Chiba, Takahito

Okuma, Kae

Inaba, Koji

Takahashi, Kana

Kaneda, Tomoya

Kashihara, Tairo

Takahashi, Ayaka

Shimizu, Yuri

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Issue Date

2022-02-06

Type

Article

Language

en_US

Keywords

Hyaluronate Acid Injection , Brachytherapy , Cervical Cancer

Abstract

Purpose: Hyaluronate gel has been injected as a spacer into the rectovaginal fossa and vesicouterine fossa during brachytherapy for patients with cervical cancer at our institution. The effect of hyaluronate gel injection (HGI) on dose-volume parameters was investigated in this study. Methods and Materials: Between July 2008 to January 2020, a total of 104 patients (non-HGI group: 52 patients; HGI group: 52 patients) who underwent curative radiation therapy for cervical cancer were selected. The total doses of external beam radiation therapy and brachytherapy for high-risk clinical target volume (CTVHR) D90, bladder D2cc, and rectal D2cc were converted to the equivalent dose in 2 Gy fractions (EQD2) and were analyzed for association with HGI. Results: Median CTVHR D90 (EQD2) in the non-HGI group was 76.0 Gy (63.7-99.5 Gy), and in the HGI group it was 79.4 Gy (52.6-97.5 Gy) (P = .017). The median bladder D2cc and rectal D2cc (EQD2) were 62.9 Gy and 56.0 Gy in the non-HGI group and 63.7 Gy and 54.8 Gy in the HGI group, which had no significant difference. Conclusions: In cases with HGI, a significant CTVHR D90 dose increase was obtained with sufficient bladder and rectal doses suppression.

Citation

Kobayashi, R., Murakami, N., Chiba, T., Okuma, K., Inaba, K., Takahashi, K., Kaneda, T., Kashihara, T., Takahashi, A., Shimizu, Y., Nakayama, Y., Kato, T., Ito, Y., & Igaki, H. (2022). Effect of Hyaluronate Acid Injection on Dose-Volume Parameters in Brachytherapy for Cervical Cancer. Advances in radiation oncology, 7(3), 100918. https://doi.org/10.1016/j.adro.2022.100918

Publisher

Advances in Radiation Oncology