Prevalence and distribution of human papillomavirus genotypes (1997–2019) and their association with cervical cancer and precursor lesions in women from southern Mexico

Alarcón-Romero, Luz del Carmen; Organista-Nava, Jorge; Gómez-Gómez, Yazmín; Ortiz-Ortiz, Julio; Hernández-Sotelo, Daniel; Moral-Hernández, Oscar del; Mendoza-Catalán, Miguel Angel; Antaño-Arias, Ramón; Leyva-Vázquez, Marco Antonio; Sales-Linares, Natividad; Antonio-Véjar, Verónica; Illades-Aguiar, Berenice

Prevalence and distribution of human papillomavirus genotypes (1997–2019) and their association with cervical cancer and precursor lesions in women from southern Mexico

Files

10.1177_10732748221103331.pdf (1.44 MB)

Authors

Alarcón-Romero, Luz del Carmen

Organista-Nava, Jorge

Gómez-Gómez, Yazmín

Ortiz-Ortiz, Julio

Hernández-Sotelo, Daniel

Moral-Hernández, Oscar del

Mendoza-Catalán, Miguel Angel

Antaño-Arias, Ramón

Leyva-Vázquez, Marco Antonio

Sales-Linares, Natividad

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Issue Date

2022-05-24

Type

Article

Language

en_US

Keywords

Human Papilloma Virus , Low-Risk HPV , Probable High-Risk HPV , High-Risk HPV , Undifined-Risk HPV , Single-Genotype HPV Infection , Multiple-Type HPV Infection

Abstract

Background: Cervical cancer (CC) is the fourth most common malignancy of the female genital tract. Human Papillomavirus (HPV) is the main cause of precancerous lesions and CC cases worldwide Objective: We assessed the prevalence and distribution of HPV types and their association with precancerous lesions and CC. Methods: HPV genotypes were detected by 3 methods depending on the year of in which the sample was analyzed: MY09/11 RFLPs (1997 to 2010), GP5+/6+ primer systems (2005 to 2010) and INNO-LiPA HPV Genotyping Extra (2010 to 2019) in cervical samples (No-IL: 4445; LSIL: 2464; HSILs: 151 and CC: 253) from women from southern Mexico. Results: The overall HPV prevalence was 54.17%, and hpv-16 was the most common genotype. In single infection, the high-risk HPV genotypes (group 1) were associated with squamous intraepitelial lesions (LSIL: HPV–39 (OR = 10.58, 95% CI 4.09–27.36, P < .001); HSIL: HPV-31 (OR = 14.76, 95% CI 6.56–33.20, P < .001); and CC: HPV-16 (OR = 25.01, 95% CI 18.83–33.21, P < .001). In multiple infections, the HPV genotypes (HPV-16 and HPV-18) were also associated with a high risk of lesions [LSIL: HPV-18 (OR = 3.45; 95% CI 1.36–8.91; P = .009); HSIL: HPV-18 (OR = 5.12; 95% CI 1.21–21.68; P = .026); and CC: HPV-16 (OR = 3.03; 95% CI 1.72–5.32; P < .001)] compared to single infection. In the analysis adjusted for age, giving birth, and cigarette smoking, a significant increase in the risk of LSIL, HSIL, and CC was maintained. Conclusions: This study provides current data on the prevalence and distribution of HPV genotypes in women from southern Mexico, which could serve as a valuable reference to guide nationwide CC screening programs and provide scientific evidence that could be useful for vaccine development efforts. Likewise, it was identified that infection with carcinogenic HPV genotypes is an independent risk factor for LSIL, HSIL, and CC.

Citation

Alarcón-Romero LDC, Organista-Nava J, Gómez-Gómez Y, Ortiz-Ortiz J, Hernández-Sotelo D, Del Moral-Hernández O, Mendoza-Catalán MA, Antaño-Arias R, Leyva-Vázquez MA, Sales-Linares N, Antonio-Véjar V, Illades-Aguiar B. Prevalence and Distribution of Human Papillomavirus Genotypes (1997-2019) and Their Association With Cervical Cancer and Precursor Lesions in Women From Southern Mexico. Cancer Control. 2022 Jan-Dec;29:10732748221103331. doi: 10.1177/10732748221103331. PMID: 35608056; PMCID: PMC9136461.

Publisher

Cancer Control