Using LongSAGE to detect biomarkers of cervical cancer potentially amenable to optical contrast agent labelling
Loading...
Authors
Kneller, Julie M.
Ehlen, Thomas
Matisic, Jasenka P.
Miller, Dianne
Niekerk, Dirk Van
Lam, Wan L.
Marra, Marco
Richards-Kortum, Rebecca
Follen, Michelle
MacAulay, Calum
Issue Date
2007-12-11
Type
Article
Language
en_US
Keywords
LongSAGE , Cervical Cancer , Biomarker , Optical Imaging
Alternative Title
Abstract
Sixteen longSAGE libraries from four different clinical stages of cervical intraepithelial neoplasia have enabled us to identify novel cell-surface biomarkers indicative of CIN stage. By comparing gene expression profiles of cervical tissue at early and advanced stages of CIN, several genes are identified to be novel genetic markers. We present fifty-six cell-surface gene products differentially expressed during progression of CIN. These cell surface proteins are being examined to establish their capacity for optical contrast agent binding. Contrast agent visualization will allow real-time assessment of the physiological state of the disease process bringing vast benefit to cancer care. The data discussed in this publication have been submitted to NCBIs Gene Expression Omnibus (GEO, http://www.ncbi.nlm.nih.gov/geo/) and are accessible through GEO Series accession number GSE6252.
Description
Citation
Kneller, J. M., Ehlen, T., Matisic, J. P., Miller, D., Van Niekerk, D., Lam, W. L., Marra, M., Richards-Kortum, R., Follen, M., Macaulay, C., & Jones, S. J. (2007). Using LongSAGE to Detect Biomarkers of Cervical Cancer Potentially Amenable to Optical Contrast Agent Labelling. Biomarker insights, 2, 447–461.
Publisher
Biomarker Insights