Preoperative nomogram for the identification of lymph node metastasis in early cervical cancer

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dc.contributor.authorKim, D-Y
dc.contributor.authorShim, S-H
dc.contributor.authorKim, S-O
dc.contributor.authorLee, S-W
dc.contributor.authorPark, J-Y
dc.contributor.authorSuh, D-S
dc.contributor.authorKim, J-H
dc.contributor.authorKim, Y-M
dc.contributor.authorKim, Y-T
dc.contributor.authorNam, J-H
dc.date.accessioned2023-01-10T17:57:28Z
dc.date.available2023-01-10T17:57:28Z
dc.date.issued2013-11-14
dc.description.abstractBackground: The objective of this study is to construct a preoperative nomogram predicting lymph node metastasis (LNM) in early-cervical cancer patients. Methods: Between 2009 and 2012, 493 early-cervical cancer patients received hysterectomy and pelvic/para-aortic lymphadenectomy. Patients who were diagnosed during 2009–2010 were assigned to a model-development cohort (n=304) and the others were assigned to a validation cohort (n=189). A multivariate logistic model was created from preoperative clinicopathologic data, from which a nomogram was developed and validated. A predicted probability of LNM<5% was defined as low risk. Results: Age, tumour size assessed by magnetic resonance imaging, and LNM assessed by positron emission tomography/computed tomography were independent predictors of nodal metastasis. The nomogram incorporating these three predictors demonstrated good discrimination and calibration (concordance index=0.878; 95% confidence interval (CI), 0.833−0.917). In the validation cohort, the discrimination accuracy was 0.825 (95% CI, 0.736−0.895). In the model-development cohort, 34% of them were classified as low risk and negative predictive value (NPV) was 99.0%. In the validation cohort, 38% were identified as low risk and NPV was 95.8%. Integrating the model-development and validation cohorts, negative likelihood ratio was 0.094 (95% CI, 0.036−0.248). Conclusion: A robust nomogram predicting LNM in early cervical cancer was developed. This model may improve clinical trial design and help physicians to decide whether lymphadenectomy should be performed.en_US
dc.identifier.citationKim, D. Y., Shim, S. H., Kim, S. O., Lee, S. W., Park, J. Y., Suh, D. S., Kim, J. H., Kim, Y. M., Kim, Y. T., & Nam, J. H. (2014). Preoperative nomogram for the identification of lymph node metastasis in early cervical cancer. British journal of cancer, 110(1), 34–41. https://doi.org/10.1038/bjc.2013.718en_US
dc.identifier.otherDOI: 10.1038/bjc.2013.718
dc.identifier.urihttps://hdl.handle.net/20.500.14041/5373
dc.language.isoen_USen_US
dc.publisherBritish Journal of Canceren_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subjectCervical Canceren_US
dc.subjectLymphatic Metastasisen_US
dc.subjectLymph Node Excisionen_US
dc.subjectNomogramen_US
dc.subjectLikelihood Functionsen_US
dc.titlePreoperative nomogram for the identification of lymph node metastasis in early cervical canceren_US
dc.typeArticleen_US
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