Associations of sexually transmitted infections and bacterial vaginosis with abnormal cervical cytology: A cross-sectional survey with 9090 community women in China
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Authors
Li, Wu
Liu, Lan-Lan
Luo, Zhen-Zhou
Han, Chun-Yan
Wu, Qiu-Hong
Zhang, Li
Tian, Li-Shan
Yuan, Jun
Zhang, Tao
Chen, Zhong-Wei
Issue Date
2020-03-26
Type
Article
Language
en_US
Keywords
Sexually Transmitted Infections , Bacterial Vaginosis , Community Women
Alternative Title
Abstract
Background:
Although it is well acknowledged that persistent infection with high-risk human papillomavirus types in genital sites plays a crucial role in the development of squamous cell cervical carcinoma, there is no unanimous consensus on the association between non-HPV sexually transmitted infections and abnormal cervical cytology.
Methods:
In the present study, we evaluated cervical cytology status, sexually transmitted infections and bacterial vaginosis status, and collected social-demographic information among recruited participants to explore the association of STIs and bacterial vaginosis with abnormal cervical cytology.
Results:
9,090 women’s specimens were successfully tested, with a total of 8,733 (96.1%) women had normal cytology and 357 (3.9%) women exhibited abnormal cytology. The prevalence of HPV, Chlamydia trachomatis, Neisseria gonorrhoeae, and bacterial vaginosis was significantly higher in the ≥ASC-US group than the NILM group (P<0.05). Women with Neisseria gonorrhoeae infection (AOR = 5.30, 95% CIs = 1.30–21.51, P = 0.020) or bacterial vaginosis (AOR = 1.94, 95% CIs = 1.08–3.47, P = 0.026) exhibited an increased risk of abnormal cervical cytology after adjusted for carcinogenic HPV-positive status.
Conclusions:
Our results demonstrated that Neisseria gonorrhoeae infection in genital sites and/or bacterial vaginosis may independently increase the risk for cervical cytology abnormalities after adjusted for carcinogenic HPV-positive status. Besides, these results improved our understanding of the etiology of abnormal cervical cytology and may be useful for the management of women with ASC-US cytology.
Description
Citation
Li, W., Liu, L. L., Luo, Z. Z., Han, C. Y., Wu, Q. H., Zhang, L., Tian, L. S., Yuan, J., Zhang, T., Chen, Z. W., Yang, T. B., Feng, T. J., Zhang, M., & Chen, X. S. (2020). Associations of sexually transmitted infections and bacterial vaginosis with abnormal cervical cytology: A cross-sectional survey with 9090 community women in China. PloS one, 15(3), e0230712. https://doi.org/10.1371/journal.pone.0230712
Publisher
PloS One