Significance of the number and the location of metastatic lymph nodes in locally recurrent or persistent cervical cancer patients treated with salvage hysterectomy plus lymphadenectomy
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Authors
Mabuchi, Seiji
Komura, Naoko
Kodama, Michiko
Maeda, Michihide
Matsumoto, Yuri
Kamiura, Shoji
Issue Date
2022-07-11
Type
Article
Language
en_US
Keywords
Recurrent Cervical Cancer , Lymph Node Metastasis , Salvage Hysterectomy , Lymphadenectomy , Survival
Alternative Title
Abstract
We retrospectively investigated the significance of metastatic lymph nodes in patients with locally recurrent or persistent cervical cancer in a previously irradiated field and subsequently had salvage hysterectomy. Clinical data were obtained from a chart review, and the prognostic impact of the presence, number (1–2 versus ≥3), and location (pelvic versus pelvic plus para-aortic) of lymph node metastasis was investigated by comparing recurrence and survival. In total, 50 patients were included in this study, of which 21 (42.0%) showed pathological evidence of lymph node metastasis (node-positive group). Both the univariate and multivariate analyses showed that lymph node metastasis was an independent prognostic factor for postoperative recurrence (hazard ratio (HR) 5.36; 95% CI 1.41–6.66; p = 0.0020). The predominant sites of recurrence after salvage surgery were the visceral organs and lymph nodes in the node-negative and node-positive groups, respectively. Patients with ≥3 node metastases showed similar survival to those with 1–2 node metastases. Patients with pelvic node metastasis showed similar survival to those with pelvic and para-aortic node metastases. The presence, not number or location, of lymph node metastasis was an independent poor prognostic factor for post-operative recurrence in patients who developed locally recurrent or persistent cervical cancer treated with salvage hysterectomy plus lymphadenectomy.
Description
Citation
Mabuchi, S., Komura, N., Kodama, M., Maeda, M., Matsumoto, Y., & Kamiura, S. (2022). Significance of the Number and the Location of Metastatic Lymph Nodes in Locally Recurrent or Persistent Cervical Cancer Patients Treated with Salvage Hysterectomy plus Lymphadenectomy. Current oncology (Toronto, Ont.), 29(7), 4856–4867. https://doi.org/10.3390/curroncol29070385
Publisher
Current Oncology (Toronto, Ont.)