Clinicopathological risk factors for recurrence after neoadjuvant chemotherapy and radical hysterectomy in cervical cancer

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dc.contributor.authorWang, Huali
dc.contributor.authorZhu, Lin
dc.contributor.authorLu, Weihua
dc.contributor.authorXu, Hui
dc.contributor.authorYu, Yunhai
dc.contributor.authorYang, Yongxia
dc.date.accessioned2023-01-09T18:31:42Z
dc.date.available2023-01-09T18:31:42Z
dc.date.issued2013-11-25
dc.description.abstractBackground: Cervical cancer is one of the common gynecological malignancies with a high recurrence rate after surgery. This study aimed to analyze the clinicopathological risk factors for recurrence after the surgical treatment of cervical cancer and provide the basis for the prevention of recurrence and an improvement of prognosis. Methods: A total of 424 cervical cancer cases between 1 January 1998 and 31 December 2011 undergoing surgical treatment were studied retrospectively, of which 23 cases had recurrences. Relevant recurrence risk factors were evaluated by univariate and multivariate analyses between recurrence group and non-recurrence group. Results: Using univariate analysis, tumor differentiation, clinical stage, pelvic lymph node metastasis, postoperative radiotherapy and postoperative chemotherapy were related to recurrence of cervical cancer. Multivariate COX model analysis revealed that pelvic lymph node metastasis and postoperative chemotherapy had an impact on recurrence rate. Moderately and highly differentiated tumor, advanced clinical stage, and positive pelvic lymph nodes indicated a high recurrence rate of cervical cancer. Postoperative chemotherapy and radiotherapy can effectively reduce the recurrence rate. Conclusions: In conclusion, cervical lymph node metastasis and postoperative chemotherapy are two independent factors for recurrence of cervical cancer after radical surgery.en_US
dc.identifier.citationWang, H., Zhu, L., Lu, W., Xu, H., Yu, Y., & Yang, Y. (2013). Clinicopathological risk factors for recurrence after neoadjuvant chemotherapy and radical hysterectomy in cervical cancer. World journal of surgical oncology, 11, 301. https://doi.org/10.1186/1477-7819-11-301en_US
dc.identifier.otherDOI: 10.1186/1477-7819-11-301
dc.identifier.urihttps://hdl.handle.net/20.500.14041/5322
dc.language.isoen_USen_US
dc.publisherWorld Journal of Surgical Oncologyen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subjectCervical Canceren_US
dc.subjectRadical Hysterectomyen_US
dc.subjectRecurrenceen_US
dc.subjectRisk Factorsen_US
dc.titleClinicopathological risk factors for recurrence after neoadjuvant chemotherapy and radical hysterectomy in cervical canceren_US
dc.typeArticleen_US
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