Radiotherapy for Japanese elderly patients with cervical cancer: preliminary survival outcomes and evaluation of treatment-related toxicity
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Authors
Yoshida, Kenji
Sasaki, Ryohei
Nishimura, Hideki
Miyawaki, Daisuke
Kawabe, Tetsuya
Okamoto, Yoshiaki
Nakabayashi, Koji
Yoshida, Shigeki
Sugimura, Kazuro
Issue Date
2010-11-30
Type
Article
Language
en_US
Keywords
Cervical Cancer , Radiotherapy , Elderly Patients , Treatment-Related Toxicity
Alternative Title
Abstract
Purpose:
To examine the preliminary survival outcomes and treatment-related toxicity for elderly patients with cervical cancer treated with radiotherapy (RT).
Methods:
Forty patients ≥75 years old with cervical cancer who were treated with RT were evaluated. Of these 40 patients, 25 were classified as FIGO stage I or II and 15 as stage III or IVA. Thirty-five patients were treated with radical RT (RRT), and five were treated with surgery plus adjuvant RT (S + ART). External beam radiotherapy combined with high-dose-rate intracavitary brachytherapy was performed on 31 patients who were treated with RRT and on 2 patients who were treated with S + ART because of positive vaginal surgical margins. The patients’ median age was 78 years (range 75–89 years). Concurrent chemotherapy (CCT) was performed on five patients (RRT: 3, S + ART: 2).
Results:
The median follow-up period was 20 months (range 1–85 months). Only one patient could not complete RT. The 3-year overall and disease-specific survival (OS and DSS) rates for all patients were 58 and 80%, respectively. Five patients experienced Grade 3 acute toxicity; two were treated with RRT (2/35), and three were treated with S + ART (3/5, 2 of them with CCT). Two patients experienced Grade 3 late toxicity; one was treated with RRT (1/35, with CCT) and the other was treated with S + ART (1/5). No Grade 4 or higher toxicity was experienced.
Conclusions:
RRT for elderly patients with cervical cancer is generally effective and safe, but severe toxicity may occur with more aggressive treatment modalities.
Description
Citation
Yoshida, K., Sasaki, R., Nishimura, H., Miyawaki, D., Kawabe, T., Okamoto, Y., Nakabayashi, K., Yoshida, S., & Sugimura, K. (2011). Radiotherapy for Japanese elderly patients with cervical cancer: preliminary survival outcomes and evaluation of treatment-related toxicity. Archives of gynecology and obstetrics, 284(4), 1007–1014. https://doi.org/10.1007/s00404-010-1777-6
Publisher
Archives of Gynecology and Obstetrics