High-risk human papillomavirus infection in low risk women: incidence, patient characteristics, and clinical meaning for cervical cancer
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Authors
Lee, Sung Jong
Yeo, Seung Geun
Park, Dong Choon
Issue Date
2011-12-15
Type
Article
Language
en_US
Keywords
HPV Infection , Screening Test
Alternative Title
Abstract
Objective: To investigate the incidence of high-risk human papillomavirus (HPV) infection and its clinical meaning.
Methods: Total 28,339 women attending our hospital for routine gynecologic care underwent Papanicolaou test (PAP test) and high-risk HPV tests. Biopsies were taken from some women and their results were compared.
Results: The prevalence of high-risk HPV infection is 24.15%. And the women aged 20-29 years had the highest prevalence (32.3%) compared to 30-70 years (P<0.05). Of the 28,339 women, 1369 (4.83%) had positive PAP test (ASCUS, LSIL, HSIL). Of the 1369 PAP-positive patients, only 16 (1.17%) were negative for HPV test. Of the 1353 patients positive on both tests, 510 (37.7%) had lesions higher than CINII on histology. Of the 1,611 patients who underwent biopsies, 350 underwent the loop electrical excision procedure, with 339 (96%) being positive for HPV test, including 16 with CINI, 48 with CINII/III, 74 with CIS, and 16 with cervical cancer. HPV test had a positive predictive value of 40.7% and a negative predictive value of 100% for higher than CINII.
Conclusion: Although HPV test has a burden of cost, considering its high negative predictive value, HPV test should be considered for more useful screening test.
Description
Citation
Lee, S. J., Yeo, S. G., & Park, D. C. (2012). High-risk human papillomavirus infection in low risk women: incidence, patient characteristics, and clinical meaning for cervical cancer. International journal of medical sciences, 9(1), 103–107. https://doi.org/10.7150/ijms.9.103
Publisher
International Journal of Medical Sciences