Clinical utility of red blood cell distribution width for the diagnosis and prognosis of cervical cancer
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Authors
Li, Yanyan
Li, Zhanzhan
Zhang, Guangying
Issue Date
2022-03-06
Type
Article
Language
en_US
Keywords
Cervical Carcinoma , Red Blood Cell Distribution Width , Diagnostic , Prognosis
Alternative Title
Abstract
Background:
The width of red blood cell distribution (RDW) is correlated with some diseases, but its clinical value and prognostic role in cervical cancer is unclear.
Methods:
We used receiver operating characteristic curves to evaluate the diagnostic ability of RDW and other clinical parameters in cervical cancer based on a case–control design. Using retrospective data, we explored the correlation of RDW with overall (OS) and progression-free (PFS) survival using Kaplan–Meier analysis and univariate and multivariate Cox regression with the hazard ratio (HR) and 95% confidence interval (CI). A restricted cubic plot was used to evaluate the nonlinear association between RDW and prognosis risk.
Results:
RDW was significantly higher in cases than in controls (14.6±1.7 vs 12.5±1.8, P<0.001). It showed high diagnostic accuracy for cervical cancer, with a sensitivity of 79.3%, specificity of 65.6%, and area under the curve of 0.802 (95% CI, 0.775–0.827) with a cutoff value of 13.88. There was a significant positive correlation between RDW and C-reactive protein (r=0.434, P=0.023). Multivariate Cox regression indicated that it was independently associated with a poorer PFS (HR, 2.05; 95% CI, 1.25–3.18, P<0.001) and OS (HR, 2.73; 95% CI, 1.61–4.64, P<0.001). RDW>14.66 showed a nonlinear increased risk for a poor PFS and OS.
Conclusion:
RDW is an easy, quick, and inexpensive tool for the early detection and risk management of cervical cancer. A greater RDW is associated with a poor prognosis in cervical cancer.
Description
Citation
Li, Y., Li, Z., & Zhang, G. (2022). Clinical Utility of Red Blood Cell Distribution Width for the Diagnosis and Prognosis of Cervical Cancer. International journal of general medicine, 15, 2597–2606. https://doi.org/10.2147/IJGM.S354569
Publisher
International Journal of General Medicine