Outcomes of laser conization for cervical intraepithelial neoplasia 2-3 and microinvasive cervical cancer
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Authors
Kanayama, Seiji
Nakagawa, Eriko
Ueno, Sayaka
Muraji, Miho
Wakahashi, Senn
Sudo, Tamotsu
Yamada, Takashi
Yamaguchi, Satoshi
Fujiwara, Kiyoshi
Nishimura, Ryuichiro
Issue Date
2014-05-06
Type
Article
Language
en_US
Keywords
Conization , Cervical Intraepithelial Neoplasia , Microinvasive Cervical Cancer , Laser
Alternative Title
Abstract
Background:
Currently, there is no standardized follow-up protocol for patients who undergo laser conization. Therefore, we retrospectively investigated the clinical outcomes of laser conization in patients with high-grade cervical intraepithelial neoplasia 2-3 (CIN 2-3) and microinvasive squamous cell carcinoma and assessed the risks of residual and recurrent lesions of the cervix uteri.
Methods:
The medical and pathological records of 91 patients with CIN 2, 580 with CIN 3 and 73 with microinvasive cervical cancer (MIC) who underwent laser conization between January 2000 and December 2011 were retrospectively reviewed.
Results:
Positive margins increased with the extent of disease and were observed in 5.5%, 8.9% and 16.4% patients with CIN 2, CIN 3 and MIC, respectively, while residual or recurrent disease was observed in 0%, 3.2% and 13.6% patients, respectively. Examination of specimens obtained through postconization biopsy or hysterectomy revealed that 1.5% and 20% patients with negative and positive margins, respectively, were diagnosed with residual or recurrent lesions. Among patients who were conservatively managed after conization, seven with CIN 3 exhibited residual or recurrent disease, as evidenced by abnormal cytological findings, within 2 years after conization.
Conclusions:
Continuous follow-up by cytology and colposcopy, particularly during the first 2 years after conization, can effectively detect early residual or recurrent disease in CIN 3 and MIC patients, regardless of their margin status.
Description
Citation
Kanayama, S., Nakagawa, E., Ueno, S., Muraji, M., Wakahashi, S., Sudo, T., Yamada, T., Yamaguchi, S., Fujiwara, K., & Nishimura, R. (2014). Outcomes of Laser Conization for Cervical Intraepithelial Neoplasia 2-3 and Microinvasive Cervical Cancer. World journal of oncology, 5(2), 62–67. https://doi.org/10.14740/wjon799w
Publisher
World Journal of Oncology