Hypothalamic-pituitary-ovarian axis disorders impacting female fertility

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dc.contributor.authorMikhael, Sasha
dc.contributor.authorPunjala-Patel, Advaita
dc.contributor.authorGavrilova-Jordan, Larisa
dc.date.accessioned2022-09-29T04:01:17Z
dc.date.available2022-09-29T04:01:17Z
dc.date.issued2019-01-04
dc.description.abstractThe hypothalamic-pituitary-ovarian (HPO) axis is a tightly regulated system controlling female reproduction. HPO axis dysfunction leading to ovulation disorders can be classified into three categories defined by the World Health Organization (WHO). Group I ovulation disorders involve hypothalamic failure characterized as hypogonadotropic hypogonadism. Group II disorders display a eugonadal state commonly associated with a wide range of endocrinopathies. Finally, group III constitutes hypergonadotropic hypogonadism secondary to depleted ovarian function. Optimal evaluation and management of these disorders is based on a careful analysis tailored to each patient. This article reviews ovulation disorders based on pathophysiologic mechanisms, evaluation principles, and currently available management options.en_US
dc.identifier.citationMikhael, S., Punjala-Patel, A., & Gavrilova-Jordan, L. (2019). Hypothalamic-Pituitary-Ovarian Axis Disorders Impacting Female Fertility. Biomedicines, 7(1), 5. https://doi.org/10.3390/biomedicines7010005en_US
dc.identifier.otherDOI: 10.3390/biomedicines7010005
dc.identifier.urihttps://hdl.handle.net/20.500.14041/2021
dc.language.isoen_USen_US
dc.publisherBiomedicinesen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subjectOvulatory Dysfunctionen_US
dc.subjectHypothalamic-Pituitary-Ovarian Axisen_US
dc.subjectWHO Ovulation Disordersen_US
dc.subjectPrimary Ovarian Insufficiencyen_US
dc.subjectFemale Fertilityen_US
dc.titleHypothalamic-pituitary-ovarian axis disorders impacting female fertilityen_US
dc.typeArticleen_US
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