Hypothalamic-pituitary-ovarian axis disorders impacting female fertility
Loading...
Authors
Mikhael, Sasha
Punjala-Patel, Advaita
Gavrilova-Jordan, Larisa
Issue Date
2019-01-04
Type
Article
Language
en_US
Keywords
Ovulatory Dysfunction , Hypothalamic-Pituitary-Ovarian Axis , WHO Ovulation Disorders , Primary Ovarian Insufficiency , Female Fertility
Alternative Title
Abstract
The hypothalamic-pituitary-ovarian (HPO) axis is a tightly regulated system controlling female reproduction. HPO axis dysfunction leading to ovulation disorders can be classified into three categories defined by the World Health Organization (WHO). Group I ovulation disorders involve hypothalamic failure characterized as hypogonadotropic hypogonadism. Group II disorders display a eugonadal state commonly associated with a wide range of endocrinopathies. Finally, group III constitutes hypergonadotropic hypogonadism secondary to depleted ovarian function. Optimal evaluation and management of these disorders is based on a careful analysis tailored to each patient. This article reviews ovulation disorders based on pathophysiologic mechanisms, evaluation principles, and currently available management options.
Description
Citation
Mikhael, S., Punjala-Patel, A., & Gavrilova-Jordan, L. (2019). Hypothalamic-Pituitary-Ovarian Axis Disorders Impacting Female Fertility. Biomedicines, 7(1), 5. https://doi.org/10.3390/biomedicines7010005
Publisher
Biomedicines