Radiosensitizers in cervical cancer. cisplatin and beyond
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Authors
Candelaria, Myrna
Garcia-Arias, Alicia
Cetina, Lucely
Dueñas-Gonzalez, Alfonso
Issue Date
2006-05-08
Type
Article
Language
en_US
Keywords
Radiosensitizers , Cervical Cancer , Cisplatin
Alternative Title
Abstract
Cervical cancer continues to be a significant health burden worldwide. Globally, the majority of cancers are locally advanced at diagnosis; hence, radiation remains the most frequently used therapeutical modality. Currently, the value of adding cisplatin or cisplatin-based chemotherapy to radiation for treatment of locally advanced cervical cancer is strongly supported by randomized studies and meta-analyses. Nevertheless, despite these significant achievements, therapeutic results are far from optimal; thus, novel therapies need to be assayed. A strategy currently being investigated is the use of newer radiosensitizers alone or in combination with platinum compounds. In the present work, we present preclinical information on known and newer cytotoxic agents as radiosensitizers on cervical cancer models, as well as the clinical information emanating from early phase trials that incorporate them to the cervical cancer management. In addition, we present the perspectives on the combined approach of radiation therapy and molecular target-based drugs with proven radiosensitizing capacity.
Description
Citation
Candelaria, M., Garcia-Arias, A., Cetina, L., & Dueñas-Gonzalez, A. (2006). Radiosensitizers in cervical cancer. Cisplatin and beyond. Radiation oncology (London, England), 1, 15. https://doi.org/10.1186/1748-717X-1-15
Publisher
Radiation Oncology (London, England)