The association of preoperative PET-CT and survival in patients with resectable cervical cancer
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Authors
Su, Chih-Hsiung
Chen, Wan-Ming
Chen, Ming-Chih
Shia, Ben-Chang
Wu, Szu-Yuan
Issue Date
2022-12-01
Type
Article
Language
en_US
Keywords
Preoperative 18FDG-PET–CT , Cervical Cancer , Surgery , Survival , Stages
Alternative Title
Abstract
Purpose: No randomized study with a long-term follow-up has investigated the effect of pretreatment 18-fluorodeoxyglucose positron emission tomography–computed tomography (18FDG-PET–CT) on the survival of patients with stage IB-IIA cervical cancer receiving curative surgery. Therefore, in this propensity score–matched, population-based cohort study, we investigated the effect of preoperative 18FDG-PET–CT on the survival outcomes of patients with potentially resectable cervical cancer. Patients and Methods: We included 2550 patients with stage IB-IIA cervical cancer receiving curative surgery with complete data on clinical stages. The patients were categorized into two 1:4 propensity, score–matched groups depending on whether they underwent pretreatment 18FDG-PET–CT, and their outcomes were compared. Results: We included 2030 and 520 patients with cervical cancer in the non-pretreatment and pretreatment PET–CT groups, respectively. Multivariable analyses revealed that the most prominent correlation between preoperative PET–CT and all-cause death was observed in the patients with stage IB–IIA cervical cancer receiving surgery (aHR [95% CI]: 1.16 [0.83–1.63]; p = 0.3752). Conclusions: Preoperative 18FDG-PET–CT was not associated with longer survival in the patients with clinical stage IB–IIA cervical cancer receiving curative surgery.
Description
Citation
Su, C. H., Chen, W. M., Chen, M. C., Shia, B. C., & Wu, S. Y. (2022). The Association of Preoperative PET-CT and Survival in Patients with Resectable Cervical Cancer. Journal of clinical medicine, 11(23), 7143. https://doi.org/10.3390/jcm11237143
Publisher
Journal of Clinical Medicine