Serum IL-6 level predicts the prognosis and diagnosis in cervical cancer patients
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Authors
Cai, Chunyan
Peng, Xing
Zhang, Yumei
Issue Date
2022-05-03
Type
Article
Language
en_US
Keywords
Interleukin-6 , Cervical Cancer , Prognosis , Diagnosis
Alternative Title
Abstract
Background:
Interleukin-6 (IL-6) has been reported to be associated with the prognosis of cancers. As for cervical cancer (CC), previous studies investigated the association between IL-6 expression in CC tumor tissue and CC prognosis; however, no studies assessed the effects of serum IL-6 levels on the survival of CC. This study aimed to explore the effects of serum IL-6 levels on prognosis in patients with CC.
Methods:
In total, 327 patients with CC and 355 controls were recruited from this hospital from May 2015 to May 2016. Serum IL-6 levels were measured before treatment. The Kaplan–Meier method was utilized to estimate survival rates. The overall survival (OS) and disease-free survival (DFS) were evaluated. The univariate and multivariate Cox regression analyses were used to identify risk factors associated with the prognosis of CC.
Results:
We found that the serum IL-6 level in the CC group was significantly higher than that in the control group. The diagnostic value of serum IL-6 level in detecting CC patients was moderate, and the specificity and sensitivity were 77.46% and 47.09%, respectively. Data suggested that the serum IL-6 level was significantly linked with the smoking status, FIGO stage, tumor size, treatment methods, and HPV infection. The univariate and multivariate analysis indicated that FIGO stage IIB-IIIC, lymph node metastasis, and high serum IL-6 levels were negatively associated with the OS and DFS in patients with CC.
Conclusion:
Serum IL-6 has a moderate diagnostic ability for detecting CC and may be a potential CC biomarker. High serum IL-6 level is associated with adverse prognosis in patients with CC and could be a prognosis indicator for CC patients.
Description
Citation
Cai, C., Peng, X., & Zhang, Y. (2022). Serum IL-6 Level Predicts the Prognosis and Diagnosis in Cervical Cancer Patients. International journal of women's health, 14, 655–663. https://doi.org/10.2147/IJWH.S347740
Publisher
International Journal of Women's Health