Non-syndromic monogenic female infertility
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Authors
Guerri, Giulia
Maniscalchi, Tiziana
Barati, Shila
Gerli, Sandro
Renzo, Gian Carlo Di
Morte, Chiara Della
Marceddu, Giuseppe
Casadei, Arianna
Laganà , Antonio Simone
Sturla, Davide
Issue Date
2019-09-30
Type
Article
Language
en_US
Keywords
Female Infertility , Premature Ovarian Failure , Ovarian Dysgenesis , Oocyte Maturation Defects , Pre-Implantation Embryonic Lethality , Recurrent Pregnancy Loss , Ovarian Hyperstimulation Syndrome
Alternative Title
Abstract
Infertility is a significant clinical problem. It affects 8-12% of couples worldwide, about 30% of whom are diagnosed with idiopathic infertility (infertility lacking any obvious cause). In 2010, the World Health Organization calculated that 1.9% of child-seeking women aged 20-44 years were unable to have a first live birth (primary infertility), and 10.5% of child-seeking women with a prior live birth were unable to have an additional live birth (secondary infertility). About 50% of all infertility cases are due to female reproductive defects. Several chromosome aberrations, diagnosed by karyotype analysis, have long been known to be associated with female infertility and monogenic mutations have also recently been found. Female infertility primarily involves oogenesis. The following phenotypes are associated with monogenic female infertility: premature ovarian failure, ovarian dysgenesis, oocyte maturation defects, early embryo arrest, polycystic ovary syndrome and recurrent pregnancy loss. Here we summarize the genetic causes of non-syndromic monogenic female infertility and the genes analyzed by our genetic test. (www.actabiomedica.it)
Description
Citation
Guerri, G., Maniscalchi, T., Barati, S., Gerli, S., Di Renzo, G. C., Della Morte, C., Marceddu, G., Casadei, A., Laganà , A. S., Sturla, D., Ghezzi, F., Garzon, S., Unfer, V., & Bertelli, M. (2019). Non-syndromic monogenic female infertility. Acta bio-medica : Atenei Parmensis, 90(10-S), 68–74. https://doi.org/10.23750/abm.v90i10-S.8763
Publisher
Atenei Parmensis