Vascular endothelial growth factor-C expression and its relationship to pelvic lymph node status in invasive cervical cancer
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Authors
Hashimoto, I.
Kodama, J.
Seki, N.
Hongo, A.
Yoshinouchi, M.
Okuda, H.
Kudo, T.
Issue Date
2001-07
Type
Article
Language
en_US
Keywords
VEGF-C , Lymph Node Metastasis , Cervical Cancer
Alternative Title
Abstract
Vascular endothelial growth factor-C (VEGF-C) has been implicated in lymphangiogenesis, the process of new lymphatics formation. The present study investigated VEGF-C mRNA expression in invasive cervical cancer tissue. Additionally, the association of VEGF-C mRNA with clinicopathological features was examined. VEGF-C mRNA expression was assessed by reverse transcription-polymerase chain reaction using β-action as an internal control. 75 patients presenting with invasive cervical cancer were included in the trial. VEGF-C mRNA expression was markedly higher in tumours in which pelvic lymph node metastasis was diagnosed by magnetic resonance (MR) imaging (P = 0.002). 53 patients displaying stage Ib–IIb cervical cancer underwent radical hysterectomy and pelvic lymphadenectomy. VEGF-C expression was significantly higher in tumours exhibiting deep stromal invasion, pelvic lymph node metastasis and lymph-vascular space involvement (P = 0.016, P = 0.006 and P = 0.036, respectively). Multivariate analysis revealed VEGF-C mRNA expression to be the sole independent factor influencing pelvic lymph node metastasis. Subjects demonstrating VEGF-C mRNA expression displayed significantly poorer prognoses than those lacking VEGF-C mRNA expression (P = 0.049). These findings provide evidence supporting the involvement of VEGF-C expression in the promotion of lymph node metastasis in cervical cancer. Furthermore, examination of VEGF-C expression in biopsy specimens may be beneficial in the prediction of pelvic lymph node metastasis. © 2001 Cancer Research Campaign http://www.bjcancer.com
Description
Citation
Hashimoto, I., Kodama, J., Seki, N., Hongo, A., Yoshinouchi, M., Okuda, H., & Kudo, T. (2001). Vascular endothelial growth factor-C expression and its relationship to pelvic lymph node status in invasive cervical cancer. British journal of cancer, 85(1), 93–97. https://doi.org/10.1054/bjoc.2001.1846
Publisher
British Journal of Cancer