Ovarian hormones-autophagy-immunity axis in menstruation and endometriosis
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Authors
Shen, Hui-Hui
Zhang, Tao
Yang, Hui-Li
Lai, Zhen-Zhen
Zhou, Wen-Jie
Mei, Jie
Shi, Jia-Wei
Zhu, Rui
Xu, Feng-Yuan
Li, Da-Jin
Issue Date
2021-01-19
Type
Article
Language
en_US
Keywords
NK Cell , Autophagy , Endometrium , Estrogen , Macrophage , Menstruation , Neutrophil , Progesterone
Alternative Title
Abstract
Menstruation occurs in few species and involves a cyclic process of proliferation, breakdown and regeneration under the control of ovarian hormones. Knowledge of normal endometrial physiology, as it pertains to the regulation of menstruation, is essential to understand disorders of menstruation. Accumulating evidence indicates that autophagy in the endometrium, under the regulation of ovarian hormones, can result in the infiltration of immune cells, which plays an indispensable role in the endometrium shedding, tissue repair and prevention of infections during menstruation. In addition, abnormal autophagy levels, together with resulting dysregulated immune system function, are associated with the pathogenesis and progression of endometriosis. Considering its potential value of autophagy as a target for the treatment of menstrual-related and endometrium-related disorders, we review the activity and function of autophagy during menstrual cycles. The role of the estrogen/progesterone-autophagy-immunity axis in endometriosis are also discussed.
Description
Citation
Shen, H. H., Zhang, T., Yang, H. L., Lai, Z. Z., Zhou, W. J., Mei, J., Shi, J. W., Zhu, R., Xu, F. Y., Li, D. J., Ye, J. F., & Li, M. Q. (2021). Ovarian hormones-autophagy-immunity axis in menstruation and endometriosis. Theranostics, 11(7), 3512–3526. https://doi.org/10.7150/thno.55241
Publisher
Theranostics