Incidence rates and temporal trends of cervical cancer relating to opportunistic screening in two developed metropolitan regions of Brazil: a population-based cohort study
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Authors
Teixeira, Júlio César
Maestri, Carlos Afonso
Machado, Helymar da Costa
Zeferino, Luiz Carlos
Carvalho, Newton Sérgio de
Issue Date
2019-10-31
Type
Article
Language
en_US
Keywords
Uterine Cervical Neoplasms , Epidemiology , Public Health , Early Detection of Cancer
Alternative Title
Abstract
BACKGROUND:
Brazilian opportunistic screening programs for cervical cancer have limited impact. In the regions of two cities (Campinas and Curitiba) with high human development indices, consistent information from 96-97% of all cervical cancer cases managed within the public healthcare system is available.
OBJECTIVE:
To estimate the incidence rate (IR) and temporal trends in these regions, covering 2001-2012.
DESIGN AND SETTING:
A population-based cohort study was conducted under the assumption that all cervical cancer cases were managed in cancer referral center hospitals.
METHODS:
3,364 records (1,646 from Campinas; 1,718 from Curitiba) were analyzed to provide estimates of IR, age-standardized IR (ASR) and cervical cancer trends (shown per 100,000 women/year). Longitudinal patterns were analyzed using linear regression and shown as annual percentage change (APC); P < 0.05 for significance.
RESULTS:
Annual IR and ASR estimates for cervical cancer ranged from 3.8 to 8.0 over 2001-2012, decreasing over more recent years, and were similar for the two regions. The age-specific IR was about 50% lower among women aged 45 years or older (IR-2001/IR-2012: Campinas = 14.8/8.0; Curitiba = 18.7/8.3; P < 0.001). There was an increasing APC trend in Campinas among women aged 15-24 years, and a decreasing IR trend for squamous-cell histology in both regions (P < 0.05).
CONCLUSION:
Cervical cancer incidence estimates showed slowly decreasing trends in both regions, most evidently for women aged 45 years or older and for squamous-cell histology. These findings reflect the opportunistic nature of the population screening program, despite the comparatively high economic development level in the two regions.
Description
Citation
Teixeira, J. C., Maestri, C. A., Machado, H. D. C., Zeferino, L. C., & Carvalho, N. S. (2019). Incidence rates and temporal trends of cervical cancer relating to opportunistic screening in two developed metropolitan regions of Brazil: a population-based cohort study. Sao Paulo medical journal = Revista paulista de medicina, 137(4), 322–328. https://doi.org/10.1590/1516-3180.2018.0306220719
Publisher
Sao Paulo Medical Journal = Revista Paulista De Medicina