Association of +331G/A PgR polymorphism with susceptibility to female reproductive cancer: evidence from a meta-analysis
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Authors
Chaudhary, Sanjib
Panda, Aditya K.
Mishra, Dipti Ranjan
Mishra, Sandip K.
Issue Date
2013-01-22
Type
Article
Language
en_US
Keywords
+331G/A PgR Polymorphism , Susceptibility , Female Reproductive Cancer , Meta-Analysis
Alternative Title
Abstract
The progesterone receptor (PgR), a sex steroid hormone receptor that binds progesterone is critical for normal breast development. The PgR (+331G/A, rs10895068) promoter polymorphism is associated with cancer risk possibly by altering the expression of progesterone receptor B isoform. Previous studies have provided inconsistent results. To validate the association between the PgR +331G/A polymorphism and female reproductive cancer risk (breast, endometrial and ovarian cancer), we performed a meta-analysis of 19 studies (19,978 cases and 24,525 controls) by using the CMA Version 2 software. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the strength of the associations. The overall results indicated that the variant allele and genotypes were associated with a mild increase in overall female reproductive cancer risk (A vs. G: OR = 1.063, 95% CI = 1.001–1.129; AA+AG vs. GG: OR = 1.067, 95% CI = 1.002–1.136). The results suggest that the PgR +331G/A polymorphism might be associated with an increased female reproductive cancer risk.
Description
Citation
Chaudhary, S., Panda, A. K., Mishra, D. R., & Mishra, S. K. (2013). Association of +331G/A PgR polymorphism with susceptibility to female reproductive cancer: evidence from a meta-analysis. PloS one, 8(1), e53308. https://doi.org/10.1371/journal.pone.0053308
Publisher
PloS One