A detailed dosimetric comparison between manual and inverse plans in HDR intracavitary/interstitial cervical cancer brachytherapy
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Authors
Trnková, Petra
Baltas, Prof. Dimos
Karabis, Andreas
Stock, Markus
Dimopoulos, Johannes
Georg, Dietmar
Pötter, Prof. Richard
Kirisits, Christian
Issue Date
2011-01-14
Type
Article
Language
en_US
Keywords
Brachytherapy , Cervix , Inverse Planning , HIPO , IPSA
Alternative Title
Abstract
Purpose:
The purpose of this study was to compare two inverse planning algorithms for cervical cancer brachytherapy and a conventional manual treatment planning according to the MUW (Medical University of Vienna) protocol.
Material and methods:
For 20 patients, manually optimized, and, inversely optimized treatment plans with Hybrid Inverse treatment Planning and Optimization (HIPO) and with Inverse Planning Simulated Annealing (IPSA) were created. Dosimetric parameters, absolute volumes of normal tissue receiving reference doses, absolute loading times of tandem, ring and interstitial needles, Paddick and COIN conformity indices were evaluated.
Results:
HIPO was able to achieve a similar dose distribution to manual planning with the restriction of high dose regions. It reduced the loading time of needles and the overall treatment time. The values of both conformity indices were the lowest. IPSA was able to achieve acceptable dosimetric results. However, it overloaded the needles. This resulted in high dose regions located in the normal tissue. The Paddick index for the volume of two times prescribed dose was outstandingly low.
Conclusions:
HIPO can produce clinically acceptable treatment plans with the elimination of high dose regions in normal tissue. Compared to IPSA, it is an inverse optimization method which takes into account current clinical experience gained from manual treatment planning.
Description
Citation
Trnková, P., Baltas, D., Karabis, A., Stock, M., Dimopoulos, J., Georg, D., Pötter, R., & Kirisits, C. (2010). A detailed dosimetric comparison between manual and inverse plans in HDR intracavitary/interstitial cervical cancer brachytherapy. Journal of contemporary brachytherapy, 2(4), 163–170. https://doi.org/10.5114/jcb.2010.19497
Publisher
Journal of Contemporary Brachytherapy