A very rare case of HPV-53-related cervical cancer, in a 79-year-old woman with a previous history of negative pap cytology
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Authors
Zappacosta, Roberta
Lattanzio, Giuseppe
Viola, Patrizia
Ianieri, Manuel Maria
Gatta, Daniela Maria Pia
Rosini, Sandra
Issue Date
2014-04-15
Type
Article
Language
en_US
Keywords
Old Women , Molecular Tests , Cervical Cancer Screening , HPV-DNA Test , HPV Genotyping
Alternative Title
Abstract
The introduction of organized cervical cancer (CC) screening programs has drastically reduced the prevalence of CC. However the incidence is still too high, especially among elderly women. All guidelines strongly recommend a regular Papanicolaou (Pap) testing for young and middle-aged patients. On the other hand, many international professional societies no longer advise screening in women who have undergone hysterectomy, and in women aged 65 years and above, who have a previous history of regular Pap smears. Here we report the case of poorly differentiated CC, involving the pelvic lymph nodes and urinary bladder, occurring in a 79-year-old woman who regularly underwent Pap tests, with no reported cytological abnormalities. In this very rare case, the CC cells, as well as cells from metastatic lymph nodes and cells from urinary specimens, molecularly showed human papilloma virus (HPV)-53. With the limitations of a single case, this report brings important information to prevent CC in elderly patients: the utility of molecular tests to increase sensitivity of Pap smears in postmenopausal women; the importance of HPV-53 as one of the four “emergent” genotypes having a possible role in oncogenesis; and the presence of HPV-53 in lymph node metastases from cervical carcinoma, which would support the role of this virus in the maintenance of malignant status.
Description
Citation
Zappacosta, R., Lattanzio, G., Viola, P., Ianieri, M. M., Gatta, D. M., & Rosini, S. (2014). A very rare case of HPV-53-related cervical cancer, in a 79-year-old woman with a previous history of negative Pap cytology. Clinical interventions in aging, 9, 683–688. https://doi.org/10.2147/CIA.S57294
Publisher
Clinical Interventions in Aging