Prevalence, diversity, and risk factors for cervical HPV infection in women screened for cervical cancer in Belem, Pará, Northern Brazil
Loading...
Authors
Monteiro, Jacqueline Cortinhas
Tsutsumi, Mihoko Yamamoto
Carvalho, Deivid Oliveira de
Costa, Elenice do Carmo da Silva
Feitosa, Rosimar Neris Martins
Laurentino, Rogério Valois
Fonseca, Ricardo Roberto de Souza
Silvestre, Rodrigo Vellasco Duarte
Oliveira-Filho, Aldemir Branco
Machado, Luiz Fernando Almeida
Issue Date
2022-08-24
Type
Article
Language
en_US
Keywords
Epidemiology , Viruses , Viral Genetics , Infectious Diseases , HPV
Alternative Title
Abstract
Background: Human papillomavirus (HPV) is the most common viral sexually transmitted infection of the reproductive tract, and cervical cancer is the most common HPV-related disease. This study estimated the prevalence, diversity of HPV genotypes, and associated risk factors in women screened for cervical cancer in northern Brazil. Methods: The cross-sectional study was conducted in Belém, Pará, in the Amazon region of Brazil, and it included 162 women who were spontaneously undergoing a Pap-smear routine. Epidemiological, sexual, and health-related information was collected by interviews, and cervical samples were collected for cytological examination and HPV-DNA detection. HPV genotypes were classified as low risk (LR) and high risk (HR) by nucleotide sequencing. Results: In total, 17.3% (28/162) of the participants had HPV-DNA, and LR-HPV was the most prevalent (71.4%). Among the 13 different types of HPV detected, HPV-11 was found most frequently (12/28; 42.9%), followed by HPV-31 (3/28; 10.7%). Of the participants with cytological alterations, HPV infection was detected in only four: two were diagnosed with low-grade squamous intraepithelial lesions (15.4%), one with atypical squamous cells of undetermined significance (7.7%), and one with atypical squamous cells, cannot exclude high-grade squamous intraepithelial lesions (7.7%). Of the 61 women who presented a normal cytology, 13 (21.3%) had positive tests for HPV infection, 4 (8.2%) of which were positive for a high-risk genotype. Conclusion: The prevalence of HPV was high in Belém, Pará, and especially in women who had normal cytology results, which suggests the need for greater screening for HPV infection in women’s primary health care.
Description
Citation
Monteiro, J. C., Tsutsumi, M. Y., de Carvalho, D. O., da Silva Costa, E. D. C., Feitosa, R. N. M., Laurentino, R. V., de Souza Fonseca, R. R., Silvestre, R. V. D., Oliveira-Filho, A. B., & Machado, L. F. A. (2022). Prevalence, Diversity, and Risk Factors for Cervical HPV Infection in Women Screened for Cervical Cancer in Belém, Pará, Northern Brazil. Pathogens (Basel, Switzerland), 11(9), 960. https://doi.org/10.3390/pathogens11090960
Publisher
Pathogens (Basel, Switzerland)