Sexually transmitted infections in pregnancy: a narrative review of the global research gaps, challenges, and opportunities
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Authors
Grant, Juliana S.
Chico, R. Matthew
Lee, Anne CC.
Low, Nicola
Medina-Marino, Andrew
Molina, Rose L.
Morroni, Chelsea
Ramogola-Masire, Doreen
Stafylis, Chrysovalantis
Tang, Weiming
Issue Date
2020-08-10
Type
Article
Language
en_US
Keywords
Sexually Transmitted Infections , Challenges , Opportunities , Research Gaps , Narrative Review , Pregnancy
Alternative Title
Abstract
Background: Sexually transmitted infections (STI), such as chlamydial, gonorrheal, and trichomonal infections, are prevalent in pregnant women in many countries and are widely reported to be associated with increased risk of poor maternal and neonatal outcomes. Syndromic STI management is frequently used in pregnant women in low- and middle-income countries, yet its low specificity and sensitivity lead to both overtreatment and undertreatment. Etiologic screening for chlamydial, gonorrheal, and/or trichomonal infection in all pregnant women combined with targeted treatment might be an effective intervention. However, the evidence base is insufficient to support the development of global recommendations. We aimed to describe key considerations and knowledge gaps regarding chlamydial, gonorrheal, and trichomonal screening during pregnancy to inform future research needed for developing guidelines for low- and middle-income countries.
Methods: We conducted a narrative review based on PubMed and clinical trials registry searches through January 20, 2020, guidelines review, and expert opinion. We summarized our findings using the frameworks adopted by the World Health Organization for guideline development.
Results: Adverse maternal-child health outcomes of potential interest are wide-ranging and variably defined. No completed randomized controlled trials on etiologic screening and targeted treatment were identified. Evidence from observational studies was limited, and trials of presumptive STI treatment have shown mixed results. Subgroups that might benefit from specific recommendations were identified. Evidence on harms was limited. Cost-effectiveness was influenced by STI prevalence and availability of testing infrastructure and high-accuracy/low-cost tests. Preliminary data suggested high patient acceptability.
Description
Citation
Grant, J. S., Chico, R. M., Lee, A. C., Low, N., Medina-Marino, A., Molina, R. L., Morroni, C., Ramogola-Masire, D., Stafylis, C., Tang, W., Vallely, A. J., Wynn, A., Yeganeh, N., & Klausner, J. D. (2020). Sexually Transmitted Infections in Pregnancy: A Narrative Review of the Global Research Gaps, Challenges, and Opportunities. Sexually transmitted diseases, 47(12), 779–789. https://doi.org/10.1097/OLQ.0000000000001258
Publisher
Sexually Transmitted Diseases