Second malignancies following primary cervical cancer diagnosis: analysis of the SEER database
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Authors
Akinyemi, Oluwasegun A.
Abodunrin, Faith O.
Andine, Tsion F.
Nasef, Kindha Elleissy
Akinwumi, Bolarinwa
Oduwole, Ayobami
Lipscombe, Christina
Ojo, Ademola S.
Fakorede, Mary
Issue Date
2022-06-21
Type
Article
Language
en_US
Keywords
Gynecologic Oncology Surgery , Cytoreductive Surgery (CRS) , Overall Survival (OS) , Second Cancers , Cervical Cancer Screening
Alternative Title
Abstract
Introduction:
While mortality following primary cervical cancers (PCCs) continues to decline due to advancements in screening and treatment, a small subset of women who developed PCCs will develop second malignancies after their initial diagnosis. Little is known about these women.
Objective:
This study aims to determine the common second malignancies among patients with primary cervical cancers and the factors associated with improved overall survival.
Methodology:
We conducted a retrospective analysis of all PCCs in the SEER database between 1975 and 2016. We identified a subset of patients who subsequently developed secondary malignancies after a primary cervical cancer diagnosis. We then determined the factors associated with a prolonged latency interval, defined as the time between the PCC diagnosis and a subsequent secondary malignancy diagnosis. In a sub-analysis, we also determined the commonest secondary malignancies following a PCC diagnosis.
Results:
A total of 1,494 patients with cervical cancers developed a second malignancy during the study period. The mean age at diagnosis of the PCCs was 56.0 ± 14.0 years. The mean latency interval between PCC and a subsequent secondary malignancy was 9.6 ± 9.3 years. Cytoreductive surgery (odds ratio (OR) = 1.40; 95% confidence interval (CI) = 1.05-1.86) and radiotherapy (OR = 1.52; 95% CI = 1.14-2.03) during the PCC are associated with a prolonged latency interval.
Patients who received chemotherapy (OR = 0.23; 95% CI = 0.16-0.33) or those of Hispanic ethnicity (OR = 0.63; 95% CI = 0.44-0.90) were more likely to develop second malignancies within 10 years after a PCC diagnosis. The most common second malignancies were abdominal malignancies with rectal cancers (12.2%), pancreatic cancers (10.1%), stomach cancers (9.2%), cecum cancers (8.4%), and sigmoid colon cancers (8.3%).
Conclusion:
There is a significant association between Hispanic ethnicity and a shorter latency interval among patients with PCC. The findings from this study may help optimize screening for secondary cancers among cervical cancer survivors.
Description
Citation
Akinyemi, O. A., Abodunrin, F. O., Andine, T. F., Elleissy Nasef, K., Akinwumi, B., Oduwole, A., Lipscombe, C., Ojo, A. S., & Fakorede, M. (2022). Second Malignancies Following Primary Cervical Cancer Diagnosis: Analysis of the SEER Database. Cureus, 14(6), e26171. https://doi.org/10.7759/cureus.26171
Publisher
Cureus