Neoadjuvant chemotherapy and less invasive surgery for the management of early stage cervical cancer: a brief report from Botswana
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Authors
Grover, Surbhi
Luckett, Rebecca
Bhatia, Rohini K.
Ralefala, Tlotlo
Seiphetlheng, Alexander
Ramogola-Masire, Doreen
Monare, Barati
Bazzett-Matabele, Lisa
Schmeler, Kathleen
Gaolebale, Ponatshego Andrew
Issue Date
2022-06-22
Type
Article
Language
en_US
Keywords
Cervical Cancer , Neoadjuvant Chemotherapy , Hysterectomy , LMICs
Alternative Title
Abstract
The majority of deaths from cervical cancer occur in low- and middle- income countries (LMICs). The standard of care for early-stage cervical cancer (FIGO 2018 IA2-IB1) is radical hysterectomy, a procedure performed by trained gynecologic oncologists. However, the lack of gynecologic oncologists in LMICs has required exploration into other methods of treatment for early-stage cervical cancer. A potential course of treatment for early-stage cervical cancer is neoadjuvant chemotherapy followed by simple hysterectomy and pelvic lymph node sampling, which can be performed by a general gynecologist. We gathered data for 8 women who underwent this method of treatment and found that cause-specific survival was 100% over a 3.5-year median follow-up. These findings support the exploration for this method of treatment for early-stage cervical cancer in LMICs, which would improve access to treatment for these women and hopefully reduce the high burden of cervical cancer related deaths in LMICs.
Description
Citation
Grover, S., Luckett, R., Bhatia, R. K., Ralefala, T., Seiphetlheng, A., Ramogola-Masire, D., Monare, B., Bazzett-Matabele, L., Schmeler, K., & Gaolebale, P. A. (2022). Neoadjuvant chemotherapy and less invasive surgery for the management of early stage cervical cancer: A brief report from Botswana. Gynecologic oncology reports, 42, 101032. https://doi.org/10.1016/j.gore.2022.101032
Publisher
Gynecologic Oncology Reports