Anti-Ma2 paraneoplastic encephalitis in association with recurrent cervical cancer
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Authors
Ney, Douglas E.
Messersmith, Wells
Behbakht, Kian
Issue Date
2014-07-03
Type
Article
Language
en_US
Keywords
Paraneoplastic Syndromes , Cervical Cancer , Anti-Ma2 Encephalitis
Alternative Title
Abstract
Background:
Paraneoplastic neurological syndromes are rare, and although they are frequently associated with gynecological malignancies, cervical cancer is a rare cause. The symptoms of anti-Ma2 encephalitis are diverse and often present prior to the diagnosis of malignancy.
Case Report:
We report a case of a 37-year-old woman with a history of cervical cancer presenting with unexplained weight gain and vertical supranuclear gaze palsy. Magnetic resonance imaging of the brain revealed lesions within the bilateral hypothalami and midbrain. Anti-Ma2 antibodies were eventually found in the serum, prompting a search for malignancy. Recurrent metastatic cervical cancer was found in the retroperitoneal lymph nodes.
Conclusions:
This is the first report of cervical cancer in association with anti-Ma2 encephalitis, and highlights the need for a high degree of suspicion in patients with a cancer history presenting with neurological symptoms. The symptoms associated with anti-Ma2 encephalitis are diverse and typically precede the diagnosis of cancer in patients, and should trigger a search for an underlying malignancy.
Description
Citation
Ney, D. E., Messersmith, W., & Behbakht, K. (2014). Anti-ma2 paraneoplastic encephalitis in association with recurrent cervical cancer. Journal of clinical neurology (Seoul, Korea), 10(3), 262–266. https://doi.org/10.3988/jcn.2014.10.3.262
Publisher
Journal of Clinical Neurology (Seoul, Korea)