Role of protein biomarkers in the detection of high-grade disease in cervical cancer screening programs
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Authors
Brown, Charlotte A.
Bogers, Johnannes
Sahebali, Shaira
Depuydt, Christophe E.
Prins, Frans De
Malinowski, Douglas P.
Issue Date
2012-02-28
Type
Article
Language
en_US
Keywords
Protein Biomarkers , High-Grade Disease , Cervical Cancer Screening Programs
Alternative Title
Abstract
Since the Pap test was introduced in the 1940s, there has been an approximately 70% reduction in the incidence of squamous cell cervical cancers in many developed countries by the application of organized and opportunistic screening programs. The efficacy of the Pap test, however, is hampered by high interobserver variability and high false-negative and false-positive rates. The use of biomarkers has demonstrated the ability to overcome these issues, leading to improved positive predictive value of cervical screening results. In addition, the introduction of HPV primary screening programs will necessitate the use of a follow-up test with high specificity to triage the high number of HPV-positive tests. This paper will focus on protein biomarkers currently available for use in cervical cancer screening, which appear to improve the detection of women at greatest risk for developing cervical cancer, including Ki-67, p16INK4a, BD ProEx C, and Cytoactiv HPV L1.
Description
Citation
Brown, C. A., Bogers, J., Sahebali, S., Depuydt, C. E., De Prins, F., & Malinowski, D. P. (2012). Role of protein biomarkers in the detection of high-grade disease in cervical cancer screening programs. Journal of oncology, 2012, 289315. https://doi.org/10.1155/2012/289315
Publisher
Journal of Oncology