Radiation therapy with chemotherapy for patients with cervical cancer and supraclavicular lymph node involvement
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Authors
Lee, Seok Ho
Lee, Seung Heon
Lee, Kyu Chan
Lee, Kwang Beom
Shin, Jin Woo
Park, Chan Yong
Sym, Sun Jin
Lee, Jun-Ho
Issue Date
2012-07-02
Type
Article
Language
en_US
Keywords
Cervical Cancer , Chemotherapy , Radiation Therapy , Supraclavicular Lymph Node
Alternative Title
Abstract
Objective:
We wanted to evaluate the outcomes of cervical cancer patients with supraclavicular lymph node (SCLN) involvement and who received radiation therapy (RT) combined with chemotherapy.
Methods:
From August 2001 to April 2009, nine cervical cancer patients with SCLN involvement were treated by RT and cisplatin-based chemotherapy. Most of the patients (8/9, 88.9%) also had a positive para-aortic lymph node (PALN). The RT field was designed to include the whole pelvis, the involved PALNs and the SCLN area. The median SCLN RT dose was 66.6 Gy (range, 60 to 70 Gy).
Results:
The median follow-up period was 61 months (range, 13 to 98 months). The 3- and 5-year overall survival rates were 66.7% and 55.6%, respectively and the 3- and 5-year progression-free survival rates were 66.7% and 44.4%, respectively. The acute hematologic toxicities according to the criteria of Radiation Therapy of Oncology Group (RTOG) were G1/2 leucopenia in 3 (33.3%), G3/4 leukopenia in 6 (66.7%), G1/2 anemia in 7 (77.8%), G3 anemia in 1 (11.1%), G2 thrombocytopenia in 2 (22.2%), and G3/4 thrombocytopenia in 2 (22.2%). Within 6 months after RT, most of the patients (5/6, 83.3%) recovered from the G3/4 leukopenia, except for 1 patient who received chemotherapy after completing RT due to subsequent bone metastasis.
Conclusion:
For patients with advanced cervix cancer and SCLN involvement, RT with chemotherapy as active therapy can be expected to provide favorable results, although there is an increased risk of G3/4 hematologic toxicity.
Description
Citation
Lee, S. H., Lee, S. H., Lee, K. C., Lee, K. B., Shin, J. W., Park, C. Y., Sym, S. J., & Lee, J. H. (2012). Radiation therapy with chemotherapy for patients with cervical cancer and supraclavicular lymph node involvement. Journal of gynecologic oncology, 23(3), 159–167. https://doi.org/10.3802/jgo.2012.23.3.159
Publisher
Journal of Gynecologic Oncology