The microRNA-218~Survivin axis regulates migration, invasion, and lymph node metastasis in cervical cancer

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dc.contributor.authorKogo, Ryunosuke
dc.contributor.authorHow, Christine
dc.contributor.authorChaudary, Naz
dc.contributor.authorBruce, Jeff
dc.contributor.authorShi, Wei
dc.contributor.authorHill, Richard P.
dc.contributor.authorZahedi, Payam
dc.contributor.authorYip, Kenneth W.
dc.contributor.authorLiu, Fei-Fei
dc.date.accessioned2023-01-18T18:19:57Z
dc.date.available2023-01-18T18:19:57Z
dc.date.issued2014-12-25
dc.description.abstractCervical cancer is the third most common cancer in women worldwide. In the present study, global microRNA profiling for 79 cervical cancer patient samples led to the identification of miR-218 down-regulation in cervical cancer tissues compared to normal cervical tissues. Lower miR-218 expression was associated significantly with worse overall survival (OS), disease-free survival (DFS), and pelvic/aortic lymph node recurrence. In vitro, miR-218 over-expression decreased clonogenicity, migration, and invasion. Survivin (BIRC5) was subsequently identified as an important cervical cancer target of miR-218 using in silico prediction, mRNA profiling, and quantitative real-time PCR (qRT-PCR). Concordant with miR-218 over-expression, survivin knockdown by siRNA decreased clonogenicity, migration, and invasion. YM155, a small molecule survivin inhibitor, significantly suppressed tumor growth and lymph node metastasis in vivo. Our findings demonstrate that the miR-218~survivin axis inhibits cervical cancer progression by regulating clonogenicity, migration, and invasion, and suggest that the inhibition of survivin could be a potential therapeutic strategy to improve outcome in this disease.en_US
dc.identifier.citationKogo, R., How, C., Chaudary, N., Bruce, J., Shi, W., Hill, R. P., Zahedi, P., Yip, K. W., & Liu, F. F. (2015). The microRNA-218~Survivin axis regulates migration, invasion, and lymph node metastasis in cervical cancer. Oncotarget, 6(2), 1090–1100. https://doi.org/10.18632/oncotarget.2836en_US
dc.identifier.otherDOI: 10.18632/oncotarget.2836
dc.identifier.urihttps://hdl.handle.net/20.500.14041/5644
dc.language.isoen_USen_US
dc.publisherOncotargeten_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subjectmiR-218en_US
dc.subjectSurvivinen_US
dc.subjectCervical Canceren_US
dc.subjectMigrationen_US
dc.subjectInvasionen_US
dc.titleThe microRNA-218~Survivin axis regulates migration, invasion, and lymph node metastasis in cervical canceren_US
dc.typeArticleen_US
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