MiR-218 impairs tumor growth and increases chemo-sensitivity to cisplatin in cervical cancer
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Authors
Li, Jiarui
Ping, Zhang
Ning, Hui
Issue Date
2012-11-28
Type
Article
Language
en_US
Keywords
miR-218 , Cervical Cancer , HeLa , Cisplatin
Alternative Title
Abstract
MicroRNAs are noncoding RNA molecules of 18–25 nucleotides that regulate gene expression at the post-transcriptional levels. Recent data revealed that miR-218 played key roles in tumor metastasis. Here, we described the regulation and function of miR-218 in cervical cancer. Overexpression of miR-218 reduced the proliferation of the human cervical cancer cell line HeLa and induced cell apoptosis through the AKT-mTOR signaling pathway. In addition, it forced expression of miR-218 suppressed tumor growth in the orthotopic mouse model of HeLa cells. Furthermore, miR-218 increased chemosensitivity to cisplatin (CDDP) in vitro. Our results indicated that targeting miR-218 may provide a strategy for blocking the development of cervical cancer.
Description
Citation
Li, J., Ping, Z., & Ning, H. (2012). MiR-218 impairs tumor growth and increases chemo-sensitivity to cisplatin in cervical cancer. International journal of molecular sciences, 13(12), 16053–16064. https://doi.org/10.3390/ijms131216053
Publisher
International Journal of Molecular Sciences