The application of liquid-based cytological detection for P16, cytologic evaluation and high-risk human papillomavirus testing in cervical cancer screening: a clinical evaluation
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Authors
Zhao, Fang
Ma, Deyong
Wang, Tingting
Zhang, Yan
Dong, Ying
Zhao, Jian
Issue Date
2022-07-28
Type
Article
Language
en_US
Keywords
Biomarkers , Liquid-Based Cytology , P16 , HR-HPV , Screening of High-Grade Cervical Lesions
Alternative Title
Abstract
Objective:
The aim of this study was to clinically evaluate the application of liquid-based cytology P16, cytologic evaluation, and high-risk human papillomavirus (HR-HPV) testing in cervical cancer screening.
Methods:
This study screened 900 women, who attended the outpatient clinic, according to the exclusion criteria of study participants. The study participants’ screening results of liquid-based cytology P16, cytologic evaluation, and HR-HPV testing were analyzed. According to the pathological results of the biopsy, the efficacy of different screening strategies for the identification of high-grade lesions was evaluated.
Results:
The positive rate of p16 expression increased with the severity of cervical lesions. P16 had the highest sensitivity and negative predictive value in identifying high-grade lesions (98.45% and 99.67%, respectively). Liquid-based Papanicolaou test (LBP), on the other hand, had the lowest sensitivity (85.27%) but the highest specificity (85.88%). HR-HPV’s positive predictive value and accuracy rate were the lowest (32.77% and 70.03%, respectively). The difference was statistically significant (P < 0.05). Dual combinations of certain tests were set up for this study; P16+LBP, HPV+LBP, and P16+HPV had sensitivities of 98.45%, 96.90%, and 99.22%, and specificities of 80.29%, 63.42%, and 64.33%, respectively. The P16 screening rates of histological and liquid-based cytology approaches were 75.74%.
Conclusion:
Compared with traditional LBP+HPV, the application of a test that solely screen for P16 or the combined screening method that involves the screening of P16 is more effective in identifying high-grade lesions.
Description
Citation
Zhao, F., Ma, D., Wang, T., Zhang, Y., Dong, Y., & Zhao, J. (2022). The Application of Liquid-Based Cytological Detection for P16, Cytologic Evaluation and High-Risk Human Papillomavirus Testing in Cervical Cancer Screening: A Clinical Evaluation. International journal of women's health, 14, 965–973. https://doi.org/10.2147/IJWH.S365236
Publisher
International Journal of Women's Health