Role of PACAP in female fertility and reproduction at gonadal level – recent advances

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dc.contributor.authorReglodi, Dora
dc.contributor.authorTamas, Andrea
dc.contributor.authorKoppan, Miklos
dc.contributor.authorSzogyi, Donat
dc.contributor.authorWelke, Laura
dc.date.accessioned2022-09-28T03:07:28Z
dc.date.available2022-09-28T03:07:28Z
dc.date.issued2012-08-11
dc.description.abstractPituitary adenylate cyclase activating polypeptide (PACAP) is a pleiotropic neuropeptide, first isolated from hypothalamic extracts, but later shown in peripheral organs, such as endocrine glands, gastrointestinal system, cardiovascular system, and reproductive organs. PACAP plays a role in fertility and reproduction. Numerous studies report on the gonadal regulatory effects of PACAP at hypothalamo-hypophyseal levels. However, the local effects of PACAP at gonadal levels are also important. The present review summarizes the effects of PACAP in the ovary. PACAP and its receptors are present in the ovary, and PACAP plays a role in germ cell migration, meiotic division, follicular development, and atresia. The autocrine-paracrine hormonal effects seem to play a regulatory role in ovulation, luteinization, and follicular atrophy. Altogether, PACAP belongs to the ovarian regulatory peptides.en_US
dc.identifier.citationReglodi, D., Tamas, A., Koppan, M., Szogyi, D., & Welke, L. (2012). Role of PACAP in Female Fertility and Reproduction at Gonadal Level - Recent Advances. Frontiers in endocrinology, 3, 155. https://doi.org/10.3389/fendo.2012.00155en_US
dc.identifier.otherDOI: 10.3389/fendo.2012.00155
dc.identifier.urihttps://hdl.handle.net/20.500.14041/2011
dc.language.isoen_USen_US
dc.publisherFrontiers in Endocrinologyen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subjectPACAPen_US
dc.subjectOvulationen_US
dc.subjectLuteinizationen_US
dc.subjectFemale Fertilityen_US
dc.titleRole of PACAP in female fertility and reproduction at gonadal level – recent advancesen_US
dc.typeArticleen_US
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