Role of PACAP in female fertility and reproduction at gonadal level – recent advances
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Authors
Reglodi, Dora
Tamas, Andrea
Koppan, Miklos
Szogyi, Donat
Welke, Laura
Issue Date
2012-08-11
Type
Article
Language
en_US
Keywords
PACAP , Ovulation , Luteinization , Female Fertility
Alternative Title
Abstract
Pituitary adenylate cyclase activating polypeptide (PACAP) is a pleiotropic neuropeptide, first isolated from hypothalamic extracts, but later shown in peripheral organs, such as endocrine glands, gastrointestinal system, cardiovascular system, and reproductive organs. PACAP plays a role in fertility and reproduction. Numerous studies report on the gonadal regulatory effects of PACAP at hypothalamo-hypophyseal levels. However, the local effects of PACAP at gonadal levels are also important. The present review summarizes the effects of PACAP in the ovary. PACAP and its receptors are present in the ovary, and PACAP plays a role in germ cell migration, meiotic division, follicular development, and atresia. The autocrine-paracrine hormonal effects seem to play a regulatory role in ovulation, luteinization, and follicular atrophy. Altogether, PACAP belongs to the ovarian regulatory peptides.
Description
Citation
Reglodi, D., Tamas, A., Koppan, M., Szogyi, D., & Welke, L. (2012). Role of PACAP in Female Fertility and Reproduction at Gonadal Level - Recent Advances. Frontiers in endocrinology, 3, 155. https://doi.org/10.3389/fendo.2012.00155
Publisher
Frontiers in Endocrinology