Should helical tomotherapy replace brachytherapy for cervical cancer? case report
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Authors
Hsieh, Chen-Hsi
Wei, Ming-Chow
Hsu, Yao-Peng
Chong, Ngot-Swan
Chen, Yu-Jen
Hsiao, Sheng-Mou
Hsieh, Yen-Ping
Wang, Li-Ying
Shueng, Pei-Wei
Issue Date
2010-11-23
Type
Article
Language
en_US
Keywords
Helical Tomotherapy , Brachytherapy , Cervical Cancer
Alternative Title
Abstract
Background:
Stereotactic body radiation therapy (SBRT) administered via a helical tomotherapy (HT) system is an effective modality for treating lung cancer and metastatic liver tumors. Whether SBRT delivered via HT is a feasible alternative to brachytherapy in treatment of locally advanced cervical cancer in patients with unusual anatomic configurations of the uterus has never been studied.
Case Presentation:
A 46-year-old woman presented with an 8-month history of abnormal vaginal bleeding. Biopsy revealed squamous cell carcinoma of the cervix. Magnetic resonance imaging (MRI) showed a cervical tumor with direct invasion of the right parametrium, bilateral hydronephrosis, and multiple uterine myomas. International Federation of Gynecology and Obstetrics (FIGO) stage IIIB cervical cancer was diagnosed. Concurrent chemoradiation therapy (CCRT) followed by SBRT delivered via HT was administered instead of brachytherapy because of the presence of multiple uterine myomas with bleeding tendency. Total abdominal hysterectomy was performed after 6 weeks of treatment because of the presence of multiple uterine myomas. Neither pelvic MRI nor results of histopathologic examination at X-month follow-up showed evidence of tumor recurrence. Only grade 1 nausea and vomiting during treatment were noted. Lower gastrointestinal bleeding was noted at 14-month follow-up. No fistula formation and no evidence of haematological, gastrointestinal or genitourinary toxicities were noted on the most recent follow-up.
Conclusions:
CCRT followed by SBRT appears to be an effective and safe modality for treatment of cervical cancer. Larger-scale studies are warranted.
Description
Citation
Hsieh, C. H., Wei, M. C., Hsu, Y. P., Chong, N. S., Chen, Y. J., Hsiao, S. M., Hsieh, Y. P., Wang, L. Y., & Shueng, P. W. (2010). Should helical tomotherapy replace brachytherapy for cervical cancer? Case report. BMC cancer, 10, 637. https://doi.org/10.1186/1471-2407-10-637
Publisher
BMC Cancer