Expression of progesterone receptor a as an independent negative prognosticator for cervical cancer

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dc.contributor.authorGarrido, Fabian
dc.contributor.authorWild, Carl Mathis
dc.contributor.authorJeschke, Udo
dc.contributor.authorDannecker, Christian
dc.contributor.authorMayr, Doris
dc.contributor.authorCavailles, Vincent
dc.contributor.authorMahner, Sven
dc.contributor.authorKost, Bernd
dc.contributor.authorHeidegger, Helene H.
dc.contributor.authorVattai, Aurelia
dc.date.accessioned2023-02-20T15:13:11Z
dc.date.available2023-02-20T15:13:11Z
dc.date.issued2023-02-01
dc.description.abstractThe role of progesterone receptor A (PRA) for the survival outcome of cervical cancer patients is ambiguous. In mouse models, it has been shown that PRA plays a rather protective role in cancer development. The aim of this study was to assess its expression by immunohistochemistry in 250 cervical cancer tissue samples and to correlate the results with clinicopathological parameters including patient survival. PRA expression was positively correlated with the International Federation of Gynecology and Obstetrics (FIGO) classification scores. PRA was significantly overexpressed in adenocarcinomas compared to squamous epithelial carcinoma subtypes. Correlation analyses revealed a trend association with the HPV virus protein E6, a negative correlation with p16 and a positive correlation with EP3. PRA expression was also associated with the expression of RIP140, a transcriptional coregulator that we previously identified as a negative prognostic factor for survival in cervical cancer patients. Univariate survival analyses revealed PRA as a negative prognosticator for survival in patients with cervical adenocarcinoma. Multivariate analyses showed that simultaneous expression of RIP140 and PRA was associated with the worst survival, whereas with negative RIP140, PRA expression alone was associated with the best survival. We can therefore assume that the effect of nuclear PRA on overall survival is dependent upon nuclear RIP140 expression.en_US
dc.identifier.citationGarrido, F., Wild, C. M., Jeschke, U., Dannecker, C., Mayr, D., Cavailles, V., Mahner, S., Kost, B., Heidegger, H. H., & Vattai, A. (2023). Expression of Progesterone Receptor A as an Independent Negative Prognosticator for Cervical Cancer. International journal of molecular sciences, 24(3), 2815. https://doi.org/10.3390/ijms24032815en_US
dc.identifier.otherDOI: 10.3390/ijms24032815
dc.identifier.urihttps://hdl.handle.net/20.500.14041/5750
dc.language.isoen_USen_US
dc.publisherInternational Journal of Molecular Sciencesen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subjectProgesterone Receptor Aen_US
dc.subjectCervical Canceren_US
dc.subjectRIP140en_US
dc.subjectHPV E6en_US
dc.subjectp16en_US
dc.subjectFIGOen_US
dc.subjectNegative Prognosticatoren_US
dc.titleExpression of progesterone receptor a as an independent negative prognosticator for cervical canceren_US
dc.typeArticleen_US
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