Effect of tissue inhibitor of metalloproteinases-3 genetics polymorphism on clinicopathological characteristics of uterine cervical cancer patients in Taiwan
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Authors
Chung, Jui-Fu
Chen, Chia-Lin
Nassef, Yasser
Shiu, Bei-Hao
Wang, Chun-Hao
Kuo, Fu-Hsuan
Hsiao, Yi-Hsuan
Yang, Shun-Fa
Wang, Po-Hui
Issue Date
2022-05-29
Type
Article
Language
en_US
Keywords
Tissue Inhibitor of Metalloproteinases-3 , Single Nucleotide Polymorphisms , Uterine Cervical Cancer , Lymph Node Metastasis , 5 Years Survival
Alternative Title
Abstract
Single nucleotide polymorphisms (SNPs) of tissue inhibitor of metalloproteinases-3 (TIMP-3) have been revealed to be related to various cancers. To date, no study explores the relationships between TIMP-3 polymorphisms and uterine cervical cancer. The purposes of this research were to investigate the associations among genetic variants of TIMP-3 and development and clinicopathological factors of uterine cervical cancer, and patient 5 years survival in Taiwanese women. The study included 123 patients with invasive cancer and 97 with precancerous lesions of uterine cervix, and 300 control women. TIMP-3 polymorphisms rs9619311, rs9862 and rs11547635 were checked and their genotypic distributions were determined by real-time polymerase chain reaction. It showed that women with genotypes CT/TT in rs9862 were found to display a higher risk of developing cervical cancer with moderate and poor cell differentiation. Moreover, it revealed that cervical cancer patients carrying genotypes CC in rs9619311 exhibited a poorer 5 years survival, as compared to those with TT/TC in Taiwanese women, using univariate analysis. In addition, pelvic lymph node metastasis was determined to independently predict 5 years survival in cervical cancer patients using multivariate analysis. Conclusively, TIMP-3 SNPs polymorphisms rs9619311 are related to cervical patient survival in Taiwanese women.
Description
Citation
Chung, J. F., Chen, C. L., Nassef, Y., Shiu, B. H., Wang, C. H., Kuo, F. H., Hsiao, Y. H., Yang, S. F., & Wang, P. H. (2022). Effect of tissue inhibitor of metalloproteinases-3 genetics polymorphism on clinicopathological characteristics of uterine cervical cancer patients in Taiwan. International journal of medical sciences, 19(6), 1013–1022. https://doi.org/10.7150/ijms.72378
Publisher
International Journal of Medical Sciences