Association between high-risk HPV types, HLA DRB1* and DQB1* alleles and cervical cancer in British women
Loading...
Authors
Cuzick, J.
Terry, G.
Ho, L.
Monaghan, J.
Lopes, A.
Clarkson, P.
Duncan, I.
Issue Date
2000-03-06
Type
Article
Language
en_US
Keywords
HPV , HLA , Cervical Cancer
Alternative Title
Abstract
Cervical scrapes from 116 British women referred with cervical cancer were tested for the presence of high oncogenic risk human papillomavirus (HPV) genotypes (HPVhr). Ninety-four per cent of the scrapes had one or more of these virus types and 66% were HPV16-positive. HPV18 was more frequent in adenocarcinoma. No evidence was found for an increased cancer risk associated with the HPV16 E6 350G variant. The HLA DRB1* and DQB1* alleles in these women and in 155 women with normal cytology and negative for HPVhrDNA were compared. DQB1*0301 alone (2P = 0.02) and in combination with DRB1*0401 (2P = 0.02) was found to be associated with cervical cancer. This was more marked in cancers positive for HPV types other than HPV16. In contrast, DRB1*1501 alone and in combination with DQB1*0602 was not significantly elevated in cancers overall, but did show some excess in HPV16-positive cancers (2P = 0.05), associated with HPV16-positive cervical cancers. Taking all cancers together, a marginally significant protective effect was found for DQB1*0501 (2P = 0.03) but no protective effect could be seen for DRB1*1301. © 2000 Cancer Research Campaign
Description
Citation
Cuzick, J., Terry, G., Ho, L., Monaghan, J., Lopes, A., Clarkson, P., & Duncan, I. (2000). Association between high-risk HPV types, HLA DRB1* and DQB1* alleles and cervical cancer in British women. British journal of cancer, 82(7), 1348–1352. https://doi.org/10.1054/bjoc.1999.1103
Publisher
British Journal of Cancer