Resveratrol against cervical cancer: evidence from in vitro and in vivo studies
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Authors
Nadile, Matteo
Retsidou, Maria Ilektra
Gioti, Katerina
Beloukas, Apostolos
Tsiani, Evangelia
Issue Date
2022-12-10
Type
Article
Language
en_US
Keywords
Cervical Cancer , Resveratrol , Proliferation , Survival , Apoptosis , Signaling Cascades
Alternative Title
Abstract
Cervical cancer affects many women worldwide, with more than 500,000 cases diagnosed and approximately 300,000 deaths each year. Resveratrol is a natural substance of the class of phytoalexins with a basic structure of stilbenes and has recently drawn scientific attention due to its anticancer properties. The purpose of this review is to examine the effectiveness of resveratrol against cervical cancer. All available in vitro and in vivo studies on cervical cancer were critically reviewed. Many studies utilizing cervical cancer cells in culture reported a reduction in proliferation, cell cycle arrest, and induction of apoptosis. Apart from apoptosis, induction of autophagy was seen in some studies. Importantly, many studies have shown a reduction in the HPV oncoproteins E6 and E7 and increased levels of the tumor suppressor p53 with resveratrol treatment. A few studies examined the effects of resveratrol administration in mice ectopic-xenografted with cervical cancer cells showing reduced tumor volume and weight. Overall, the scientific data show that resveratrol has the ability to target/inhibit certain signaling molecules (EGFR, VEGFR, PKC, JNK, ERK, NF-kB, and STAT3) involved in cervical cancer cell proliferation and survival. Further in vivo experiments and clinical studies are required to better understand the potential of resveratrol against cervical cancer.
Description
Citation
Nadile, M., Retsidou, M. I., Gioti, K., Beloukas, A., & Tsiani, E. (2022). Resveratrol against Cervical Cancer: Evidence from In Vitro and In Vivo Studies. Nutrients, 14(24), 5273. https://doi.org/10.3390/nu14245273
Publisher
Nutrients