Short-course palliative radiotherapy for uterine cervical cancer
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Authors
Kim, Dong Hyun
Lee, Ju Hye
Ki, Yong Kan
Nam, Ji Ho
Kim, Won Taek
Jeon, Ho Sang
Park, Dahl
Kim, Dong Won
Issue Date
2013-12-31
Type
Article
Language
en_US
Keywords
Cervix Uteri , Carcinoma , Palliation , Hypofractionation , Radiotherapy
Alternative Title
Abstract
Purpose:
The purpose of this retrospective study was to evaluate the efficacy and feasibility of short-course hypofractionated radiotherapy (RT) for the palliation of uterine cervical cancer.
Materials and Methods:
Seventeen patients with cancer of the uterine cervix, who underwent palliative hypofractionated 3-dimensional conformal radiotherapy between January 2002 and June 2012, were retrospectively analyzed. RT was delivered to symptomatic lesions (both the primary mass and/or metastatic regional lymph nodes). The total dose was 20 to 25 Gy (median, 25 Gy) in 5 Gy daily fractions.
Results:
The median follow-up duration was 12.2 months (range, 4 to 24 months). The median survival time was 7.8 months (range, 4 to 24 months). Vaginal bleeding was the most common presenting symptom followed by pelvic pain (9 patients). The overall response rates were 93.8% and 66.7% for vaginal bleeding control and pelvic pain, respectively. Nine patients did not have any acute side effects and 7 patients showed minor gastrointestinal toxicity. Only 1 patient had grade 3 diarrhea 1 week after completion of treatment, which was successfully treated conservatively. Late complications occurred in 4 patients; however, none of these were of grade 3 or higher severity.
Conclusion:
Short-course hypofractionated RT was effective and well tolerated as palliative treatment for uterine cervical cancer.
Description
Citation
Kim, D. H., Lee, J. H., Ki, Y. K., Nam, J. H., Kim, W. T., Jeon, H. S., Park, D., & Kim, D. W. (2013). Short-course palliative radiotherapy for uterine cervical cancer. Radiation oncology journal, 31(4), 216–221. https://doi.org/10.3857/roj.2013.31.4.216
Publisher
Radiation Oncology Journal