Genetic susceptibility of cervical cancer
Loading...
Authors
Chen, Xiaojun
Jiang, Jie
Shen, Hongbing
Hu, Zhibin
Issue Date
2011-05
Type
Article
Language
en_US
Keywords
Cervical Cancer , Genetic , Human Papillomavirus
Alternative Title
Abstract
Epidemiological and laboratory-based studies have identified infection with one of 15 high-risk human papillomavirus (HPV) types as a necessary but not sufficient cause of cervical cancer. The prevalence of genital HPV infections is high in young women, but most of the infections regress without interventions. Host genetic variations in genes involved in immune response pathways may be related to HPV clearance, and HPV E6/E7 oncoproteins interacting or downstream genes, both coding and non-coding, may contribute to the outcome of high risk HPV infection and cervical cancer. Of specific interest for this review has been the selection of genetic variants in genes involved in the above-referred pathways with a summary of their applications in association studies. Because the supportive and opposing data have been reported in different populations, well-designed international collaborative studies need to be conducted to define the consistency of the associations, paving the way to better define the patients at high risk of developing cervical cancer.
Description
Citation
Chen, X., Jiang, J., Shen, H., & Hu, Z. (2011). Genetic susceptibility of cervical cancer. Journal of biomedical research, 25(3), 155–164. https://doi.org/10.1016/S1674-8301(11)60020-1
Publisher
Journal of Biomedical Research