The role of chlamydia trachomatis in the pathogenesis of cervical cancer
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Authors
Franchini, Ana P Arcia
Iskander, Beshoy
Anwer, Fatima
Oliveri, Federico
Fotios, Kakargias
Panday, Priyanka
Hamid, Pousette
Issue Date
2022-01-17
Type
Article
Language
en_US
Keywords
Human Papillomavirus , Chlamydia Trachomatis , Coinfection , Cervical Intraepithelial Neoplasm , Cervical Cancer
Alternative Title
Abstract
Chlamydia trachomatis (CT) is an obligate intracellular, Gram-negative bacterium that causes a variety of infections in both humans and animals. It is the causative agent of one of the most common sexually transmitted infections (STIs) with sequelae such as pelvic inflammatory disease, ectopic pregnancy, and infertility. Furthermore, Chlamydia infections have been epidemiologically linked to cervical cancer (CC) in patients with human papillomavirus (HPV) coinfection. However, a molecular mechanism linking Chlamydia to CC is yet to be established, and we still do not know if more aggressive diagnosis and treatment of Chlamydia could possibly lead to lower incidences of CC and associated mortality. Since CC is a leading cause of death among women worldwide, and HPV infection alone is insufficient to cause cancer, our goal was to determine the link between Chlamydia, HPV, and CC. This literature review aimed to understand the pathologic model of CC and how Chlamydia might induce or promote carcinogenesis alone or alongside HPV. In addition, we compared multiple studies attempting to associate Chlamydial infection with CC in different populations and aimed to determine whether there is an epidemiological correlation or not.
Description
Citation
Arcia Franchini, A. P., Iskander, B., Anwer, F., Oliveri, F., Fotios, K., Panday, P., & Hamid, P. (2022). The Role of Chlamydia Trachomatis in the Pathogenesis of Cervical Cancer. Cureus, 14(1), e21331. https://doi.org/10.7759/cureus.21331
Publisher
Cureus