Cancer stem cells and their possible implications in cervical cancer: a short review
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Authors
Fiore, Riccardo Di
Suleiman, Sherif
Drago-Ferrante, Rosa
Subbannayya, Yashwanth
Pentimalli, Francesca
Giordano, Antonio
Calleja-Agius, Jean
Issue Date
2022-05-05
Type
Article
Language
en_US
Keywords
Cervical Cancer , Cancer Stem Cells , Drug Resistance , Radio-Resistance , EMT , Quiescence , Epigenetics , Targeted Therapy , Delivery Systems
Alternative Title
Abstract
Cervical cancer (CC) is the fourth most common type of gynecological malignancy affecting females worldwide. Most CC cases are linked to infection with high-risk human papillomaviruses (HPV). There has been a significant decrease in the incidence and death rate of CC due to effective cervical Pap smear screening and administration of vaccines. However, this is not equally available throughout different societies. The prognosis of patients with advanced or recurrent CC is particularly poor, with a one-year relative survival rate of a maximum of 20%. Increasing evidence suggests that cancer stem cells (CSCs) may play an important role in CC tumorigenesis, metastasis, relapse, and chemo/radio-resistance, thus representing potential targets for a better therapeutic outcome. CSCs are a small subpopulation of tumor cells with self-renewing ability, which can differentiate into heterogeneous tumor cell types, thus creating a progeny of cells constituting the bulk of tumors. Since cervical CSCs (CCSC) are difficult to identify, this has led to the search for different markers (e.g., ABCG2, ITGA6 (CD49f), PROM1 (CD133), KRT17 (CK17), MSI1, POU5F1 (OCT4), and SOX2). Promising therapeutic strategies targeting CSC-signaling pathways and the CSC niche are currently under development. Here, we provide an overview of CC and CCSCs, describing the phenotypes of CCSCs and the potential of targeting CCSCs in the management of CC.
Description
Citation
Di Fiore, R., Suleiman, S., Drago-Ferrante, R., Subbannayya, Y., Pentimalli, F., Giordano, A., & Calleja-Agius, J. (2022). Cancer Stem Cells and Their Possible Implications in Cervical Cancer: A Short Review. International journal of molecular sciences, 23(9), 5167. https://doi.org/10.3390/ijms23095167
Publisher
International Journal of Molecular Sciences