Dosimetric impacts of applicator displacements and applicator reconstruction-uncertainties on 3D image-guided brachytherapy for cervical cancer
| dc.contributor.author | Schindel, Joshua | |
| dc.contributor.author | Zhang, Winson | |
| dc.contributor.author | Bhatia, Sudershan K. | |
| dc.contributor.author | Sun, Wenqing | |
| dc.contributor.author | Kim, Yusung | |
| dc.date.accessioned | 2023-01-17T18:58:06Z | |
| dc.date.available | 2023-01-17T18:58:06Z | |
| dc.date.issued | 2013-12-18 | |
| dc.description.abstract | Purpose: To quantify the dosimetric impact of applicator displacements and applicator reconstruction-uncertainties through simulated planning studies of virtual applicator shifts. Material and methods: Twenty randomly selected high-dose-rate (HDR) titanium tandem-and-ovoid (T&O) plans were retrospectively studied. MRI-guided, conformal brachytherapy (MRIG-CBT) plans were retrospectively generated. To simulate T&O displacement, the whole T&O set was virtually shifted on treatment planning system in the cranial (+) and the caudal (–) direction after each dose calculation. Each shifted plan was compared to an unshifted plan. To simulate T&O reconstruction-uncertainties, each tandem and ovoid was separately shifted along its axis before performing the dose calculation. After the dose calculation, the calculated isodose lines and T&O were moved back to unshifted T&O position. Shifted and shifted-back plan were compared. Results: Regarding the dosimetric impact of the simulated T&O displacements, rectal D2cc values were observed as being the most sensitive to change due to T&O displacement among all dosimetric metrics regardless of point A (p < 0.013) or MRIG-CBT plans (p < 0.0277). To avoid more than 10% change, ± 1.5 mm T&O displacements were accommodated for both point A and MRIG-CBT plans. The dosimetric impact of T&O displacements on sigmoid (p < 0.0005), bladder (p < 0.0001), HR-CTV (p < 0.0036), and point A (p < 0.0015) were significantly larger in the MRIG-CBT plans than point A plans. Regarding the dosimetric impact of T&O reconstruction-uncertainties, less than ± 3.0 mm reconstruction-uncertainties were also required in order to avoid more than 10% dosimetric change in either the point A or MRIG-CBT plans. Conclusions: The dosimetric impact of simulated T&O displacements was significantly larger in the MRIG-CBT plans than in the point A plans. Either ± 3 mm T&O displacement or a ± 4.5 mm T&O reconstruction-uncertainty could cause greater than 10% dosimetric change for both point A plans and MRIG-CBT plans. | en_US |
| dc.identifier.citation | Schindel, J., Zhang, W., Bhatia, S. K., Sun, W., & Kim, Y. (2013). Dosimetric impacts of applicator displacements and applicator reconstruction-uncertainties on 3D image-guided brachytherapy for cervical cancer. Journal of contemporary brachytherapy, 5(4), 250–257. https://doi.org/10.5114/jcb.2013.39453 | en_US |
| dc.identifier.other | DOI: 10.5114/jcb.2013.39453 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.14041/5636 | |
| dc.language.iso | en_US | en_US |
| dc.publisher | Journal of Contemporary Brachytherapy | en_US |
| dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | * |
| dc.subject | 3D Image | en_US |
| dc.subject | Applicator Shifts | en_US |
| dc.subject | Brachytherapy | en_US |
| dc.subject | Cervical Cancer | en_US |
| dc.subject | Dosimetry | en_US |
| dc.subject | High-Dose-Rate | en_US |
| dc.title | Dosimetric impacts of applicator displacements and applicator reconstruction-uncertainties on 3D image-guided brachytherapy for cervical cancer | en_US |
| dc.type | Article | en_US |