Prognostic value of pretreatment hemoglobin level in patients with early cervical cancer
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Authors
Shin, Na-Ri
Lee, Yoo-Young
Kim, Seung-Hyun
Choi, Chel Hun
Kim, Tae-Joong
Lee, Jeong-Won
Bae, Duk-Soo
Kim, Byoung-Gie
Issue Date
2014-01-16
Type
Article
Language
en_US
Keywords
Anemia , Hemoglobins , Prognosis , Survival , Uterine Cervical Neoplasms
Alternative Title
Abstract
Objective:
The purpose of this study is to investigate the prognostic role of pretreatment anemia in patients with early cervical cancer who underwent radical hysterectomy.
Methods:
In this study, we retrospectively enrolled patients with early cervical cancer (International Federation of Obstetrics and Gynecology stage IB to IIA) who were treated at Samsung Medical Center, Seoul, Korea, from 1996 to 2007.
Results:
We retrospectively enrolled 805 patients. Median pretreatment hemoglobin (Hb) level was 12.8 g/dL (4.0-16.9) in all patients. Ninety-ninth out of 805 patients had pretreatment anemia (12.3%). Pretreatment anemia was significantly associated with large tumor size, advanced clinical stage, and parametrial invasion. In multivariate analysis, higher pretreatment Hb entailed better prognostic significance in disease free survival (hazard ratio [HR], 0.88; 95% confidence interval [CI], 0.078-0.99) but not in overall survival (HR, 0.94; 95% CI, 0.80-1.10).
Conclusion:
In conclusion, we found that the negative association between pretreatment Hb level and tumor size and the impact of anemia before treatment on disease free survival adjusted for other factors including clinical stage and pathological findings in early stage cervical cancer.
Description
Citation
Shin, N. R., Lee, Y. Y., Kim, S. H., Choi, C. H., Kim, T. J., Lee, J. W., Bae, D. S., & Kim, B. G. (2014). Prognostic value of pretreatment hemoglobin level in patients with early cervical cancer. Obstetrics & gynecology science, 57(1), 28–36. https://doi.org/10.5468/ogs.2014.57.1.28
Publisher
Obstetrics & Gynecology Science